8.A.250.  The Tubby-related Protein 3 (TULP3) Family 

TULP3 is a negative regulator of the Shh signaling transduction pathway, of 442 aas and possibly one C-terminal TMS. It is recruited to primary cilia via association with the IFT complex A (IFT-A; see family 1.X.1) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. It binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes (Santagata et al. 2001). The tubby family adapter protein TULP3, mediates the transport of most membrane cargoes into cilia (Reddy Palicharla and Mukhopadhyay 2024).