8.A.253. The TMEM45A (TMEM45A) Family
Human TMEM45A has been implicated in several disease states and several forms of cancer. For example, TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells (Flamant et al. 2012), it is involved in renal fibrosis in rats by regulating the Jagged1/Notch pathway (Lan et al. 2020), it plays a role in cancer cell sensitivity to cisplatin (Schmit et al. 2019), as well as inflammatory bowel disease (IBD) and arthritis (Verma et al. 2019) as well as keratoglobus (Weiner et al. 2021), and it regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B (Zhang et al. 2020).
References associated with 8.A.253 family:
Flamant, L., E. Roegiers, M. Pierre, A. Hayez, C. Sterpin, O. De Backer, T. Arnould, Y. Poumay, and C. Michiels. (2012). TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer 12: 391. 22954140
Lan, J.Z., Q. Pan, Q. Tao, X. Shi, W.Z. Wang, B.W. Xu, and J.W. Luo. (2020). TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway. Front Biosci (Landmark Ed) 25: 593-605. 31585906
Schmit, K., J.W. Chen, S. Ayama-Canden, M. Fransolet, L. Finet, C. Demazy, L. D'Hondt, C. Graux, and C. Michiels. (2019). Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Cell Death Dis 10: 919. 31801939
Verma, A., P. Somvanshi, S. Haque, B. Rathi, and S. Sharda. (2019). Association of Inflammatory Bowel Disease with Arthritis: Evidence from In Silico Gene Expression Patterns and Network Topological Analysis. Interdiscip Sci 11: 387-396. 29147967
Weiner, C., I. Hecht, A. Kotlyar, N. Shoshany, D. Zadok, U. Elbaz, F. Segev, A. Maytal, Y. Hachmo, C. Michiels, O. De Backer, N. Shomron, A. Einan-Lifshitz, and E. Pras. (2021). Association of Variants in TMEM45A With Keratoglobus. JAMA Ophthalmol 139: 1089-1095. 34410316
Zhang, L., F. Wu, and J. Zhao. (2020). Transmembrane protein 45A regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B. Anticancer Drugs 31: 900-907. 32568829