8.A.35.1.2
MmpS5 auxillary protein; functions with MmpL5 in the export of siderophores (Wells et al. 2013) and various drugs. Upregulation gives rise to antibiotic resistance (Briffotaux et al. 2017). Verapamil and its metabolite norverapamil inhibit the M. tuberculosis MmpS5L5 efflux pump (TC# 2.A.6.5.8) to increase bedaquiline activity (Fountain et al. 2025).
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| Accession Number: | P65381 |
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| Protein Name: | Putative membrane protein mmpS5 |
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| Length: | 142 |
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| Molecular Weight: | 15249.00 |
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| Species: | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [233413] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass membrane protein2 |
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| Substrate |
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1: MIGTLKRAWI PLLILVVVAI AGFTVQRIRT FFGSEGILVT PKVFADDPEP FDPKVVEYEV
61: SGSGSYVNIN YLDLDAKPQR IDGAALPWSL TLKTTAPSAA PNILAQGDGT SITCRITVDG
121: EVKDERTATG VDALTYCFVK SA