8.A.71 The RIC3 Protein (RIC3) Family
The resistance to Inhibitors of Cholinesterase (RIC-3) has been shown to interfere with assembly and functional maturation of ligand-gated ion channels (LGICs). The RIC3 protein of humans is 369 aas with 2 TMSs. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. It also promotes functional expression of homomeric serotoninergic 5-HT3 receptors and heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 (Halevi et al. 2003). The direct interaction of serotonin type 3A homopentamers (5-HT3A ) with RIC-3 requires the intracellular domain (ICD) of this pLGIC (Nishtala et al. 2016).
References associated with 8.A.71 family:
Castelán, F., M. Castillo, J. Mulet, S. Sala, F. Sala, E. Domínguez Del Toro, and M. Criado. (2008). Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. J Neurochem 105: 617-627. 18179477
Do, H.Q. and M. Jansen. (2023). Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors. J Gen Physiol 155:. 37026993
Halevi, S., L. Yassin, M. Eshel, F. Sala, S. Sala, M. Criado, and M. Treinin. (2003). Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. J. Biol. Chem. 278: 34411-34417. 12821669
Loring, R.H. (2022). Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly. Molecules 27:. 35889400
Nishtala, S.N., N. Mnatsakanyan, A. Pandhare, C. Leung, and M. Jansen. (2016). Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain. J Neurochem 137: 528-538. 26875553