| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.81.1.1 | The S100-A1 protein of 94 aas and 1 C-terminal TMS. Regulates TRPM1 activity (Jirku et al. 2016) and the ryanodine receptor (Chen and Kudryashev 2020). It is capable of increasing the open probability of RyR1 and may compete with calmodulin (CaM, TC# 8.A.82) for the same binding site on the receptor (Chen and Kudryashev 2020). | Eukaryota |
Metazoa, Chordata | S100-A1 of Homo sapiens |
|
8.A.81.1.2 | S100-A10 protein of 97 aas and 1 C-terminal TMS. Interacts with annexin A2 to regulate intracellular trafficking and virus entry (Dziduszko and Ozbun 2013). It also functions as a linker, tethering certain transmembrane proteins to annexin A2, thereby assisting trafficing to the plasma membrane and anchorage at certain membrane sites (Rescher and Gerke 2008). | Eukaryota |
Metazoa, Chordata | S100-A10 of Homo sapiens |
|
8.A.81.1.3 | S100-A16 of 103 aas and 1 C-terminal TMS. Binds one calcium ion per monomer (Sturchler et al. 2006). | Eukaryota |
Metazoa, Chordata |
S100-A16 of Homo sapiens |
|
8.A.81.1.4 | The S100-B protein of 92 aas. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. | Eukaryota |
Metazoa, Chordata | S100-B of Homo sapiens |
|
8.A.81.1.5 | Calgranulin B (S100A9) of 156 aas, a Ca2+-binding protein A9 that regulates the expression of genes encoding amino acid transporters. This in turn regllates genes encoding caseins, CSN1S1, 2, and 3 (Zhang et al. 2024). S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune responses. It can induce neutrophil chemotaxis, adhesion, and can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. It is predominantly found as calprotectin (S100A8/A9) which has a plethora of intra- and extracellular functions. | Eukaryota |
Metazoa, Chordata | Calgranulin B of Bos taurus (Bovine) |