TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.81.1.1









The S100-A1 protein of 94 aas and 1 C-terminal TMS.  Regulates TRPM1 activity (Jirku et al. 2016).

Eukaryota
Metazoa
S100-A1 of Homo sapiens
8.A.81.1.2









S100-A10 protein of 97 aas and 1 C-terminal TMS.  Interacts with annexin A2 to regulate intracellular trafficking and virus entry (Dziduszko and Ozbun 2013).  It also functions as a linker, tethering certain transmembrane proteins to annexin A2, thereby assisting trafficing to the plasma membrane and anchorage at certain membrane sites (Rescher and Gerke 2008).

Eukaryota
Metazoa
S100-A10 of Homo sapiens
8.A.81.1.3









S100-A16 of 103 aas and 1 C-terminal TMS.  Binds one calcium ion per monomer (Sturchler et al. 2006).

Eukaryota
Metazoa
  S100-A16 of Homo sapiens
8.A.81.1.4









The S100-B protein of 92 aas. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Eukaryota
Metazoa
S100-B of Homo sapiens