8.A.90.1.1
Uroplakin 2, UPK2, of 184 aas and 2 or 3 TMSs, 1 or 2 N-terminal and 1 C-terminal. UPK2 is a component of the asymmetric unit membrane
(AUM), a highly specialized biomembrane elaborated by terminally
differentiated urothelial cells. May play a role in
regulating the assembly of the AUM which regulates channel activities (see 8.A.40.1.1) (Chicote et al. 2017).
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| Accession Number: | O00526 |
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| Protein Name: | Uroplakin-2 |
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| Length: | 184 |
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| Molecular Weight: | 19438.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL
61: MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL
121: VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL
181: GSRK