TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.B.14.1.1









Sea anemone Class 1 toxin, BgK of 37 aas (blocks channels containing Kv1 subunits); the 3-d structure known (1BGKA) (Aneiros et al. 1993).

Eukaryota
Metazoa
Bgk of Bunodosoma granuliferum (Red warty sea anemone)
8.B.14.1.2









ShK potassium channel toxin (3-d structure known (1BEI; 1C2U_A))

Eukaryota
Metazoa
ShK Toxin of Stoichactis helianthus (P29187)
8.B.14.1.3









Sea anemone voltage-sensitive K+ channel inhibitor, Actitoxin Aeq1a; of 36 aas.  Also bolcks α-dendrotoxin binding (Minagawa et al. 1998).

Eukaryota
Metazoa
ShKT of Actina equina Beadlet anemone)
8.B.14.1.4









Uncharacterized protein of 99 aas.

Eukaryota
Metazoa
UP of Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
8.B.14.1.5









ShTK domain protein of 106 aas.

Eukaryota
Metazoa
ShTK domain protein of Necator americanus (Human hookworm)
8.B.14.1.6









K+ channel blocker of 74 aas (Jouiaei et al. 2015).  Inhibits voltage-gated potassium channels (Kv1.2/KCNA2) and facilitates acetylcholine release at the avian neuromuscular junction.

Eukaryota
Metazoa
Toxin of Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
8.B.14.2.1









Matrix metalloprotease 23 (MMP23), with a C-terminal K channel blocking Toxin Domain, TxD (residues 254 - 290; 37 aas). The NMR structure of the 37 aa toxin domain is available (2K72_A) (Rangaraju et al., 2010).

Eukaryota
Metazoa
MMP23 of Mus musculus (O88676)
8.B.14.2.2









Matrix metalloproteinase-23, MMP23B, (ADAM23, MMP21 or MMP22) of 390 aas. It regulates the surface expression of several potassium channels by retaining them in the endoplasmic reticulum (Ohnishi et al. 2001; Costa et al. 2015). ADAM22 and ADAM23 have opposite effects on Kv1.1/Kv1.4 currents, ADAM23 inhbiting and ADAM22 activating. The relative expression of these proteins may shape the expression of K+ currents in different neuronal membrane domains (Lancaster et al. 2019).

 

Eukaryota
Metazoa
ADAM23 of Homo sapiens
8.B.14.2.3









Matrix metalloproteinase-14, MMP14 or MT1-MMP, of 582 aas and 2 TMSs at the N- and C-termini. It mediates extracellular matrix (ECM) degradation following targetting and endocytosis into endolysosomes in a flotillin (TC# 8.A.21.3.1)-dependent process. MMP14 promotes cancerous growth and metastasis (Planchon et al. 2018).

 

Eukaryota
Metazoa
MMP14 of Homo sapiens
8.B.14.2.4









Karilysin, Kly, of 472 aas and 1 N-terminal TMS. Karilysin appears to be a major virulence factor of T. forsythia that contributes to evasion of the human immune response and periodontal disease.

Bacteria
Bacteroidetes
Kly of Tannerella forsythia (Bacteroides forsythus)