8.B.16.4.1
Iota-conotoxin precursor of 82 aas and 1 N-terminal TMS. Iota contoxin RXIA is 46 aas and activates Nav1.6 and Nav1.2 voltage-gated sodium channels (VGSC). It contains an inhibitory cystein knot and a D-amino acid. It contains the cysteine motif: C-C-CC-CC-C-C as do other members of the family (Robinson and Norton 2014).
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| Accession Number: | E2DEL0 |
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| Protein Name: | Iota conotoxin I1-superfamily protein |
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| Length: | 82 |
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| Molecular Weight: | 8935.00 |
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| Species: | Conus radiatus (Rayed cone) [61198] |
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| Substrate |
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1: MKLCLTFLLV LMILASVTGE KSSKHTLSRA ARVKNRGPSF CKADEKPCEY HADCCNCCLS
61: GICAPSTNWI LPGCSTSSFF KI