| TCID | Name | Domain | Kingdom/Phylum | Protein(s) | ||
|---|---|---|---|---|---|---|
|
8.B.21.1.1 | Mu-Cyrtautoxin-As1a or ApsIII insecticidal neurotoxin of 37 aas; an atypical knottin. Blocks votage-gated Na+ channels in insects (Skinner et al. 1992). It acts by pluging the outer vestibule of the channel, and also acts in combination with a weak (30%) voltage-independent block of insect voltage-gated calcium (Cav) channels (low-voltage and high-voltage channels). Tested on DUM neurons, it inhibits sodium currents with an IC50 of 540 nM. The solution structure is available (PDB# 2M36). | Eukaryota |
Metazoa, Arthropoda | APSIII of Aptostichus schlingeri | ||
|
8.B.21.1.2 | Trantula Jingzhaotoxin-59 (JzTx-59) or Theraphotoxin-Cj1a of 78 aas. Possibly related to selenoprotein P (SelP) receptor, a knottin protein (TC family 9.B.87). Fuctions to impair ion channels (Chen et al. 2008). | Eukaryota |
Metazoa, Arthropoda | JzTx-59 of Chilobrachys guangxiensis | ||
|
8.B.21.1.3 | Nemetoxin-Csp1c or toxic peptide C of 39 aas. Causes paralysis to insect larvae such as H.virescens. This knottin toxin of the insecticidal toxin ABC family, is active only on insects. | Eukaryota |
Metazoa, Arthropoda | Nemetoxin of Calisoga sp. | ||
|
8.B.21.1.4 | Uncharacterized protein of 65 aas | Eukaryota |
Viridiplantae, Streptophyta | UP of Genlisea aurea | ||
|
8.B.21.1.5 | Putative toxin of 93 aas | Eukaryota |
Fungi, Ascomycota | Toxin of Colletotrichum
orbiculare (Cucumber anthracnose fungus) (Colletotrichum lagenarium) | ||
|
8.B.21.1.6 | I superfamily conotoxin of 71 aas | Eukaryota |
Metazoa, Mollusca | Conotoxin of Conus ebraeus (Hebrew cone)
| ||
|
8.B.21.1.7 | Putative toxin, CtI-1 of 53 aas | Viruses |
CtI-1 of Dendrolimus kikuchii nucleopolyhedrovirus | |||
|
8.B.21.1.8 | Kappa conotoxin ViTx of 67 aas and 1 TMS. Inhibits various potassium channels including Kv1.1, Kv1.2, Kv1.3 and Kv1.6 (Robinson and Norton 2014). | Eukaryota |
Metazoa, Mollusca | ViTx of Conus virgo (Virgin cone) | ||
|
8.B.21.1.9 | Kappa conotoxin BTx or BeTx of 70 aas and 1 N-terminal TMS. It is a modulator of potassium channels, specifically up-modulating the calcium and voltage-gated BK channels. It has no effect on single channel conductance, but increases the open probability of BK channels (Fan et al. 2003). | Eukaryota |
Metazoa, Mollusca | BTx conotoxin of Conus betulinus (Beech cone) | ||
|
8.B.21.1.10 | Conotoxin Gla-MrII of 94 aas and 1 TMS. | Eukaryota |
Metazoa, Mollusca | Conotoxin Gla-MrII of Conus marmoreus (Marble cone) | ||
|
8.B.21.1.11 | γ-conotoxin PiVIIA of 25 aas. Micromolar concentrations of PiVIIA increased the magnitude of the macroscopic calcium current in DRG neurons from rats. An increase, even modest of the calcium current, may have a significant impact on the excitability and electrical activity of neurons, and may set up PiVIIA as a member of the pharmacological family of the gamma-conotoxins (Bernáldez et al. 2016). | None |
Pseudomonadati, Pseudomonadota | conotoxin of Conus princeps | ||
|
8.B.21.2.1 | Conotoxin of 76 aas. | Eukaryota |
Ciliophora | Conotoxin of Tetrahymena thermophila | ||
|
8.B.21.2.2 | Uncharacterized protein of 82 aas and 1 TMS. | Eukaryota |
Fungi, Ascomycota | UP of Cochliobolus sativus (Common root rot and spot blotch fungus) (Bipolaris sorokiniana) | ||
|
8.B.21.2.3 | Uncharacterized protein of 63 aas and possibly one C-terminal TMS. | Bacteroidota | UP of Kordia sp. |