8.B.25.1.6
Human herpes virus GN1 of 91 aas and 2 TMSs, N- and C-terminal. The proline hinge sequence with its highly rigid conformation serves as an anchor into the membrane. This anchor is responsible for the structural and dynamical behavior of the whole protein, constraining the mobility of the C-terminus, increasing the mobility of the transmembrane region, and controlling accessibility of the C-terminal residues to the cytoplasmic environment (Graul et al. 2023).