8.B.34.1.1
Sigma-conotoxin of 88 aas and 1 TMS. Sigma-conotoxins bind and inhibit serotonin-gated
ion channels. This peptide selectively and reversibly inhibits
5-hydroxytryptamine 3 receptor (HTR3A) through competitive antagonism
(IC50=53-86.8 nM) (England et al. 1998).
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| Accession Number: | P58924 |
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| Protein Name: | Sigma-conotoxin GVIIIA |
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| Length: | 88 |
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| Molecular Weight: | 9430.00 |
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| Species: | Conus geographus (Geography cone) [6491] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
|
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1: MMSKMGAMFV LLLLFTLASS LQEGDVQARK TRLKSDFYRA LARDDRGCTR TCGGPKCTGT
61: CTCTNSSKCG CRYNVHPSGW GCGCACSG