8.B.34. The Sigma-Conotoxin (Sigma-Conotoxin) Family
Sigma-conotoxins bind and inhibit serotonin-gated
ion channels. These peptides selectively and reversibly inhibit 5-hydroxytryptamine 3 receptors (HTR3A) through competitive antagonism
(IC50=53-86.8 nM) (England et al. 1998).
This family belongs to the: Conotoxin Superfamily.
References associated with 8.B.34 family:
England, L.J., J. Imperial, R. Jacobsen, A.G. Craig, J. Gulyas, M. Akhtar, J. Rivier, D. Julius, and B.M. Olivera. (1998). Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. Science 281: 575-578. 9677203