TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
9.B.102.1.1 | YedE; 401aas; 10 TMSs (Gristwood et al., 2011). Evidence suggests it may play a role in selenium transport (Lin et al. 2015). | Bacteria |
Pseudomonadota | YedE of E. coli (P31064) |
9.B.102.1.2 | YeeE/UPF0394 family; DUF395 (352aas; 9 or 10 TMSs) | Bacteria |
Pseudomonadota | YeeE of E. coli (P33015) |
9.B.102.1.3 | Uncharacterized protein of 363 aas and 10 TMSs (Cluster 2). | Eukaryota |
Evosea | UP of Dictyostelium discoideum |
9.B.102.1.4 | Putative permease of 228 aas and 6 TMSs (Cluster 3). | Bacteria |
Bacillota | PP of Clostridium tetani |
9.B.102.1.5 | Uncharacterized protein of 371 aas and 10 TMSs (Cluster 4). | Bacteria |
Thermodesulfobacteriota | UP of Geobacter metallireducens |
9.B.102.1.6 | Uncharacterized protein of 402 aas (cluster 5) | Archaea |
Euryarchaeota | UP of Halorubrum lacusprofundi |
9.B.102.1.7 | YeeE homologue of 172 aas. | Archaea |
Euryarchaeota | YeeE homologue of Methanosaeta harundinacea |
9.B.102.1.8 | YeeE homologue of 398 aas and 10 TMSs. | Bacteria |
Thermodesulfobacteriota | YeeE homologue of Desulfonatonospira thiodismutans |
9.B.102.1.9 | YeeE homologue of 422 aas and 11 TMSs. | Archaea |
Candidatus Thermoplasmatota | YeeE homologue of Thermoplasma acidophilum |
9.B.102.1.10 | YeeE homologue of 409 aas | Archaea |
Thermoproteota | YeeE homologue of Sulfolobus solfataricus |
9.B.102.1.11 | YeeE homologue of 329 aas and 10 TMSs | Eukaryota |
Fungi, Ascomycota | YeeE homologue of Metarhizobium anisopliae |
9.B.102.1.12 | YeeE/YedE protein with 9 TMSs and a C-terminal SirA/YedF/YeeD/YvrY domain of about 100 aas. The hydrophilic SirA α/β sandwich domain has been suggested to be involved in surface attachement and biofilm formation in enteric bacteria (Teplitski et al. 2006; Salazar et al. 2013). However, SirA/TusA/YhhP proteins bind FMN, catalyze sulfur transfer, and are important for sulfur oxidation, tRNA thiomodification and molybdenum cofactor biosynthesis (Dahl et al. 2013; Lee et al. 2013; Higgins et al. 2015) Homologues have been shown to bind sulfur via a cysteyl residue, and growth on sullfide in sufur oxidation bacteria requires such a homologue (Stockdreher et al. 2014). Genes encoding homologues of YeeD are often found sandwiched in between the two genes encoding half sized YeeE homologues of 4 or 5 TMSs. | Bacteria |
Actinomycetota | YeeE homologue of Corynebacterium efficiens |
9.B.102.1.13 | Uncharacterized YeeE homologue of 305 aas | Bacteria |
Spirochaetota | YeeE homologue of Turneriella parva |
9.B.102.1.14 | YedE homologue of 349 aas and 10 TMSs | Bacteria |
Spirochaetota | YedE of Treponema pedis |
9.B.102.1.15 | YeeE homologue of 425 aas and 10 TMSs | Bacteria |
Bacillota | YeeE homologue of Erysipelothrix rhusiopathiae |
9.B.102.1.16 | Uncharacterized protein of 333 aas and 9 TMSs | Bacteria |
Thermotogota | UP of Pseudothermotoga thermarum |
9.B.102.1.17 | Uncharacterized protein of 360 aas and 10 TMSs | Archaea |
Thermoproteota | UP of Pyrobaculum oguniense |
9.B.102.1.18 | Uncharacterized protein of 167 aas and 4 TMSs | Bacteria |
Calditrichota | UP of Caldithrix abyssi |
9.B.102.1.19 | YeeE homologue of 187 aas and 5 TMSs | Bacteria |
Bacteroidota | YeeE of Pedobacter heparinus |
9.B.102.1.20 | YeeE homologue of 157 aas and 4 TMSs | Archaea |
Euryarchaeota | YeeE homologue of Methanocaldococcus fervens (Methanococcus fervens) |
9.B.102.1.21 | Uncharacterized protein of 285 aas and 8 TMSs. | Bacteria |
Pseudomonadota | UP of Photobacterium profundum |
9.B.102.1.22 | Uncharacteerized protein of 458 aas and 10 TMSs | Archaea |
Candidatus Thermoplasmatota | UP of Thermoplasmatales archaeon I-plasma |
9.B.102.2.1 | Putative MFS permease (384aa; 10-12 TMSs) | Bacteria |
Pseudomonadota | Putative MFS permease of Thiomonas sp 3As (D6CN48) |
9.B.102.2.2 | YeeE homologue of 375 aas and 9 TMSs. | Bacteria |
Pseudomonadota | YeeE homologue of Bordetella avium |
9.B.102.2.3 | YeeE homologue of 396 aas and 10 TMSs | Bacteria |
Pseudomonadota | YeeE of Variovorax paradoxus |
9.B.102.2.4 | Uncharacterized protein of 403 aas and 12 TMSs | Bacteria |
Pseudomonadota | UP of Thalassospira profundimaris |
9.B.102.2.5 | YeeE homologue of 122 aas and 4 TMSs | Bacteria |
Candidatus Tectomicrobia | YeeE of Candidatus Entotheonella sp. TSY2 |
9.B.102.3.1 | SoxT, a putative permease encoded in an operon (soxSRT) concerned with the oxidation of both thiosulfate and tetrathionate (Lahiri et al., 2006). The putative transprter is 362aas in length with 10 putative TMSs in an apparent 2+2+2+2+2 arrangement. SoxT has been modeled after LacY with predictions of substrate binding (Bagchi 2013). | Bacteria |
Pseudomonadota | SoxT of Pseudoaminobacter salicylatoxidans (Q5ZQN6) |
9.B.102.3.2 | Uncharacterized protein of 423 aas and 9 TMSs (Cluster 1). | Bacteria |
Pseudomonadota | UP of Alkalilimnicola ehrlichei |
9.B.102.3.3 | Membrane protein of 371 aas and 9 TMSs | Bacteria |
Pseudomonadota | Membrane protein of Ramlibacter tataouinensis |
9.B.102.3.4 | Uncharacterized protein of 383 aas and 9 TMSs | Bacteria |
Pseudomonadota | UP of Aurantimonas manganoxydans |
9.B.102.3.5 | YeeE homoogue of 357 aas and 9 TMSs | Bacteria |
Pseudomonadota | YeeE of Ruegeria pomeroyi (Silicibacter pomeroyi) |
9.B.102.4.1 | Rhodanese domain-containing protein (RCP) (647aas; The 6 N-terminal TMSs are distantly related to YeeE (TC#9.B.102.1.2)) | Bacteria |
Thermodesulfobacteriota | RCP of Syntrophobacter fumaroxidans (A0LFK9) |
9.B.102.4.2 | YeeE homologue of 218 aas | Bacteria |
Myxococcota | YeeE homologue of Anaeromyxobacter dehalogenans |
9.B.102.4.3 | YeeE homologue of 185 aas | Bacteria |
Thermodesulfobacteriota | YeeE homologue of Geobacter sulfurreducens |
9.B.102.4.4 | YeeE-Rhodanese fusion protein of 419 aas | Bacteria |
Verrucomicrobiota | fusion protein of Opitutus terrae |
9.B.102.4.5 | YeeE homologue of 175 aas and 5 TMSs | Bacteria |
Bacillota | YeeE homologue of Sporomusa ovata |
9.B.102.5.1 | Putative permease of 147 aas and 4 TMSs. | Bacteria |
Pseudomonadota | Putative permease of Thiomonas sp. 3As (D6CUL1) |
9.B.102.5.2 | Putative permease subunit of 142 aas and 4 TMSs, PmpA. The N- and C-termni are predicted to be outside. It belongs to the Duf395/COG2391 family. Its structural gene, pmpA, is adjacent to pmpB (TC# 9.B.102.5.5) which encodes another small 4 TMS protein of opposite orientation in the membrane. These genes and pmpC, encoding a transporter of the TSUP family (2.A.102) that might function in sulfur or selenium metabolism (Lin et al. 2015), are localized in a gene cluster concerned with prodigiosin (red pigment (Darshan and Manonmani 2015)) production (Gristwood et al. 2011). Hence, PmpA/PmpB might export prodigiosin, but no direct evidence is available to support such a possibility. Prodigiosin is an aromatic compound that does not contain sulfur. | Bacteria |
Pseudomonadota | PmpA of Serratia sp. |
9.B.102.5.3 | Uncharacterized protein of 378 aas and 9 TMSs. The N-terminal 4 TMSs match PmpA (TC# 9.B.102.5.2) while the C-terminal 4 TMSs match PmpB (TC# 9.B.102.5.5) as top hits. Only the central TMS does not show homology. Therefore, the N-terminus of this protein may have its N-terminus inside and its C-terminus outside. Further, this provides evidence that PmpA and PmpB are two parts of a single two subunit transporter. Prodigiosin, which is hypothesized to export prodigiosin in Serratia species, could be the function of this protein since Galdieria species are sensitive to prodigiosin. Thus it could be a prodigiosin efflux pump (Lee et al. 2017). | Eukaryota |
Rhodophyta | UP of Galdieria sulphuraria |
9.B.102.5.4 | Uncharacterized protein of 353 as and 9 TMSs. Similar to TC#9.B.102.5.3 (see the description of this protein). | Eukaryota |
Rhodophyta | UP of Galdieria sulphuraria |
9.B.102.5.5 | 4 TMS protein of 142 aas, PmpB. It has N- and C-termini predicted to be on the inside. The opposite orientation is observed for PmpA (TC# 9.B.102.5.2) which in encoded by a gene adjacent to the pmpB gene. These two proteins may comprise a single two subunit transporter. These two genes are adjacent to pmpC which encodes a member of the TSUP family of sulfur compound uptake permeases (Gristwood et al., 2011, Shlykov et al., 2012). | Bacteria |
Pseudomonadota | PmpB of Serratia sp. (E7BBJ2) |
9.B.102.5.6 | YeeE homologue of 137 aas | Bacteria |
Bacteroidota | YeeE homologue of Psychroflexus torquis
|
9.B.102.5.7 | YeeE homologue of 158 aas and 4 TMSs | Bacteria |
Pseudomonadota | YeeE homologue of Thiomonas intermedia (Thiobacillus intermedius) |
9.B.102.5.8 | YeeE homologue of 369 aas and 8 TMSs | Eukaryota |
Fungi, Basidiomycota | YeeE homologue of Rhodosporidium toruloides (Yeast) (Rhodotorula gracilis) |