1,3-β-glucan synthase component, Fks1 of 1876 aas and about 11 TMSs in a 6 + 5 + 5 TMS arrangement.  1,3-beta-glucan serves as the primary component of the fungal cell wall; the synthase is located in the plasma membrane where it is a molecular target for antifungal drugs such as echinocandins and the triterpenoid ibrexafungerp. Zhao et al. 2023 presented the cryo-EM structure of Fks1 at 2.47 Å resolution. The structure revealed a central catalytic region adopting a cellulose synthase fold with a cytosolic conserved GT-A-type glycosyltransferase domain and a closed transmembrane channel responsible for glucan export. Two extracellular disulfide bonds are crucial for Fks1 enzymatic activity.