MICOS complex component, MIC60, of 758 aas and 1 N-terminal TMS. It is a determining factor for membrane curvature with the formation of cristae (Tarasenko et al. 2017).  Homologues of this protein are found in α-proteobacteria, the persumed evolutionary source of this mitochondrial protein (Alkhaja et al. 2012). It may catalyze transfer of lipids from the membranes of mitochondra to those of other organelles.  At the ultrastructural level, mutant mitochondria display loss of inner membrane organization. MINOS1/Mio10 in yeast is a constituent of Mitofilin/Fcj1 complexes in both human and yeast mitochondria (Alkhaja et al. 2012). In human mitochondria, the inner membrane MICOS complex interacts with the outer membrane sorting and assembly machinery (SAM) complex, to form the mitochondrial intermembrane space bridging complex (MIB) (Ott et al. 2015). May play a role in mitochondrial division (Cho et al. 2017).