9.B.216.1.4
MICOS complex component, MIC60, of 758 aas and 1 N-terminal TMS. It is a determining factor for membrane curvature with the formation of cristae (Tarasenko et al. 2017). Homologues of this protein are found in α-proteobacteria, the persumed evolutionary source of this mitochondrial protein (Alkhaja et al. 2012). It may catalyze transfer of lipids from the membranes of mitochondra to those of other organelles. At the ultrastructural level, mutant mitochondria display loss of inner
membrane organization. MINOS1/Mio10 in yeast is a constituent of Mitofilin/Fcj1 complexes in both human and yeast
mitochondria (Alkhaja et al. 2012). In human mitochondria, the inner membrane MICOS complex interacts with
the outer membrane sorting and assembly machinery (SAM) complex, to form
the mitochondrial intermembrane space bridging complex (MIB) (Ott et al. 2015). May play a role in mitochondrial division (Cho et al. 2017).
|
| Accession Number: | Q16891 |
|---|
| Protein Name: | MICOS complex subunit MIC60 |
|---|
| Length: | 758 |
|---|
| Molecular Weight: | 83678.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Single-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
61: TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
121: SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
181: PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
241: AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
301: ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
361: LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
421: EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
481: TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
541: TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
601: ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
661: SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
721: AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE