| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.418.1.1 | Insulin-induced gene 2 protein, INSIG2, of 225 aas and 6 TMSs. It functions with SCAP (TC# 2.A.6.6.4) to control the of enzymes and transport systems involved in the biosynthesis of cholesterol and other sterols (Yan et al. 2021). See family description for details. | Eukaryota |
Metazoa, Chordata | Insig-2 of Homo sapiens |
|
9.B.418.1.2 | Insulin-induced gene 1 protein, INSIG1, of 277 aas and 6 or 7 TMSs. Like INSIG2, it binds oxysterols, including 25-hydroxycholesterol,
regulating interaction with SCAP and retention of the SCAP-SREBP complex
in the ER (Xu et al. 2020). It also regulates degradation of SOAT2/ACAT2 when the
lipid levels are low, and initiates the ubiquitin-mediated degradation of sterol O-acyltransferase 2 (SOAT2/ACAT2) (TC# 2.A.50.4.11) via recruitment of the ubiquitin ligases AMFR/gp78 (Wang et al. 2017). It resembles INSIG2 in many functional respects (see 9.B.418.1.1). | Eukaryota |
Metazoa, Chordata | Insig-1 of Homo sapiens |
|
9.B.418.1.3 | Insulin-induced protein of 473 aas and 6 TMSs in a 1 + 1 + 4 (C-terminal) TMSs. It shows good sequence similarity to Insig-1 and -2 only in the 4 TMS C-terminal domain. | Eukaryota |
Fungi, Ascomycota | Insulin-induced protein of Ascosphaera apis |
|
9.B.418.1.4 | Uncharacterized protein of 373 aas and 10 or 11 TMSs in a 4 or 5 + 6 TMS arrangement. The last 6 TMSs are members of this family. | Bacteria |
Planctomycetota | UP of Planctomycetes bacterium |
|
9.B.418.1.5 | Uncharacterized protein of 185 aas and 6 TMSs. | Bacteria |
Myxococcota | UP of Hyalangium minutum |
|
9.B.418.1.6 | Uncharacterized protein of 213 aas and 6 TMSs. | Bacteria |
Actinomycetota | UP of Mycobacteroides salmoniphilum |
|
9.B.418.1.7 | Multidomain LON peptidase N-terminal domain and RING finger protein 1of 848 aas and about 7 TMSs in a 1 + 1 + 3 + 1 + 1 TMS arrangement. TMSs 2 - 6 are homologous to other members of this family. | Eukaryota |
Fungi, Ascomycota | Multidomain protein of Ophiocordyceps camponoti-floridani
|