9.B.418.1.1 Insulin-induced gene 2 protein, INSIG2, of 225 aas and 6 TMSs. It functions with SCAP (TC# 2.A.6.6.4) to control the of enzymes and transport systems involved in the biosynthesis of cholesterol and other sterols (Yan et al. 2021). See family description for details.
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Accession Number: | Q9Y5U4 |
Protein Name: | Insulin-induced gene 2 protein |
Length: | 225 |
Molecular Weight: | 24778.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP
61: DVIASIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
121: ASAKVDFDNN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY
181: TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE