9.B.469. The Apoptosis-inducing Factor, Mitochondria-associated 1 (AIFM1) Family
It functions both as an NADH oxidoreductase and a regulator of apoptosis (Ghezzi et al. 2010). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway.
References associated with 9.B.469 family:
Ghezzi, D., I. Sevrioukova, F. Invernizzi, C. Lamperti, M. Mora, P. D''Adamo, F. Novara, O. Zuffardi, G. Uziel, and M. Zeviani. (2010). Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am J Hum Genet 86: 639-649. 20362274
Shi, M., N. Zhou, M. Xiu, X. Li, F. Shan, W. Chen, W. Li, C.M. Chiang, X. Wu, Y. Zhang, A. Li, and J. Cao. (2024). Identification of host proteins that interact with African swine fever virus pE301R. Eng Microbiol 4: 100149. 39629325