9.B.87 The Selenoprotein P Receptor (SelP-Receptor) Family
Selenoprotein P (SelP) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain and testis as a selenium source for selenoprotein synthesis. Apolipoprotein E receptor-2 (ApoER2) is required for SelP uptake by the testis, and deletion of ApoER2 reduces testis and brain, but not kidney, selenium levels. Neither the C-terminal selenocysteine-rich domain of SelP nor ApoER2 were required for SelP uptake by proximal tubules. SelP binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium. Proximal tubules don't take up SelP in megalin null mice. Thus, kidney selenium homeostasis is mediated by a megalin-dependent SelP uptake pathway in the proximal tubule (Olson et al., 2008) that may use an endocytic mechanism (Thévenod, 2010).
Homologues of SelP receptors function in various capacities including regulation of ion transporters. Therefore, this family could be assigned to TC subclass 8.A. For example, KRP4 (TC# 9.B.87.1.24) is involved in the formation of neuromuscular junctions, and in the regluation of acetyl choline receptors (Koppel et al. 2019). However, it is retained in family 9.B.87 because several family members appear to function in other capacities, an observation consistent with the tremendous variation in protein size and domain composition of the proteins assigned to this family. Crumbs (Crb) (TC# 9.B.87.1.11) maintains apical polarity and inhibits γ-secretase cleavage of APP. It contributes to the organization of zonula adherens, epithelial morphogenesis, and tissue growth (Bachmann et al. 2001). Loss or mislocalisation of Crb is often associated with disruption of apicobasal cell polarity. crb mRNA is also apically enriched in epithelial cells, and it accumulates in the oocyte of developing egg chambers (Bhagavatula and Knust 2021).
This family belongs to the: Defensin Superfamily.
References associated with 9.B.87 family:
and Thevenod F. (2010). Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals. 23(5):857-75. 20204475
Adachi, H. and M. Tsujimoto. (2002). FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. J. Biol. Chem. 277: 34264-34270. 12077138
Al-Akhrass, H., J.R.W. Conway, A.S.A. Poulsen, I. Paatero, J. Kaivola, A. Padzik, O.M. Andersen, and J. Ivaska. (2021). A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene 40: 1300-1317. 33420373
Andersen, O.M., J. Reiche, V. Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C.A. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K.R. Bales, R. Cappai, C.L. Masters, J. Gliemann, E.J. Mufson, B.T. Hyman, S.M. Paul, A. Nykjaer, and T.E. Willnow. (2005). Neuron.al sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 102: 13461-13466. 16174740
Bachmann, A., M. Schneider, E. Theilenberg, F. Grawe, and E. Knust. (2001). Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643. 11740560
Banerji, S., J. Ni, S.X. Wang, S. Clasper, J. Su, R. Tammi, M. Jones, and D.G. Jackson. (1999). LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144: 789-801. 10037799
Basha, S., B. Jin-Smith, C. Sun, and L. Pi. (2023). The SLIT/ROBO Pathway in Liver Fibrosis and Cancer. Biomolecules 13:. 37238655
Bhagavatula, S. and E. Knust. (2021). A putative stem-loop structure in is required for mRNA localisation in epithelia and germline cells. J Cell Sci 134:. 33310910
Brecht, S., V.B. Carruthers, D.J. Ferguson, O.K. Giddings, G. Wang, U. Jakle, J.M. Harper, L.D. Sibley, and D. Soldati. (2001). The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. J. Biol. Chem. 276: 4119-4127. 11053441
Brose, K., K.S. Bland, K.H. Wang, D. Arnott, W. Henzel, C.S. Goodman, M. Tessier-Lavigne, and T. Kidd. (1999). Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96: 795-806. 10102268
Brütsch, R., S.S. Liebler, J. Wüstehube, A. Bartol, S.E. Herberich, M.G. Adam, A. Telzerow, H.G. Augustin, and A. Fischer. (2010). Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. Circ Res 107: 592-601. 20616313
Cai, K., X. Zhang, and X.C. Bai. (2022). Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors. Chem Rev. [Epub: Ahead of Print] 35715229
Chan, Y.H., F.C. Tsai, G.J. Chang, Y.J. Lai, S.H. Chang, W.J. Chen, and Y.H. Yeh. (2023). CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca-handling abnormalities: implication in cardiac arrhythmias. J Biomed Sci 30: 55. 37452346
Cheng, L., S. Zhang, F. Shang, Y. Ning, Z. Huang, R. He, J. Sun, and S. Dong. (2021). Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. Front Endocrinol (Lausanne) 12: 618037. 34040579
Costa Mendonça-Natividade, F., C. Duque Lopes, R. Ricci-Azevedo, A. Sardinha-Silva, C. Figueiredo Pinzan, A.C. Paiva Alegre-Maller, L. L Nohara, A. B Carneiro, A. Panunto-Castelo, I. C Almeida, and M.C. Roque-Barreira. (2019). Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from. Int J Mol Sci 20:. 31658592
Crosby, H.A., P.F. Lalor, E. Ross, P.N. Newsome, and D.H. Adams. (2009). Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J Hepatol 51: 734-749. 19703720
daSilva, L.L., O. Foresti, and J. Denecke. (2006). Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail. Plant Cell 18: 1477-1497. 16714388
Davis, C.G., A. Elhammer, D.W. Russell, W.J. Schneider, S. Kornfeld, M.S. Brown, and J.L. Goldstein. (1986). Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. J. Biol. Chem. 261: 2828-2838. 3005267
Ding, X., R. Fu, and F. Tian. (2020). De novo resonance assignment of the transmembrane domain of LR11/SorLA in E. coli membranes. J Magn Reson 310: 106639. 31734618
Eggert, S., C. Thomas, S. Kins, and G. Hermey. (2018). Trafficking in Alzheimer''s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol 55: 5809-5829. 29079999
Faissner, A. (2023). Low-density lipoprotein receptor-related protein-1 (LRP1) in the glial lineage modulates neuronal excitability. Front Netw Physiol 3: 1190240. 37383546
Finkelshtein, D., A. Werman, D. Novick, S. Barak, and M. Rubinstein. (2013). LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus. Proc. Natl. Acad. Sci. USA 110: 7306-7311. 23589850
Funaro, A., G.C. Spagnoli, M. Momo, W. Knapp, and F. Malavasi. (1994). Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production. Hum Immunol 40: 267-278. 7528188
Fyfe, J.C., M. Madsen, P. Højrup, E.I. Christensen, S.M. Tanner, A. de la Chapelle, Q. He, and S.K. Moestrup. (2004). The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 103: 1573-1579. 14576052
Gan, L., T. Lu, Y. Lu, H. Song, J. Zhang, K. Zhang, S. Lu, X. Wu, F. Nie, S. Di, D. Han, F. Yang, W. Qin, and W. Wen. (2024). Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8 T cell infiltration. J Immunother Cancer 12:. 39260826
Gao, X.M., D.D. Zhang, C.C. Hou, C. Du, S.Y. Luo, and J.Q. Zhu. (2020). Developmental and mRNA transcript relative abundance pattern of vitellogenin receptors, LR8-/Lrp13, during ovarian development in the large yellow croaker (Larimichthys crocea). Anim Reprod Sci 213: 106271. 31987324
Glerup, S., D. Olsen, C.B. Vaegter, C. Gustafsen, S.S. Sjoegaard, G. Hermey, M. Kjolby, S. Molgaard, M. Ulrichsen, S. Boggild, S. Skeldal, A.N. Fjorback, J.R. Nyengaard, J. Jacobsen, D. Bender, C.R. Bjarkam, E.S. Sørensen, E.M. Füchtbauer, G. Eichele, P. Madsen, T.E. Willnow, C.M. Petersen, and A. Nykjaer. (2014). SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 82: 1074-1087. 24908487
Glienke, J., A. Sturz, A. Menrad, and K.H. Thierauch. (2002). CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. Mech Dev 119: 165-175. 12464430
He, J., G. Xia, L. Yang, Z. Jiang, Y. Yang, Z. Huo, and C. Guo. (2022). Crim1 inhibits angiotensin II-induced hypertrophy and preserves Kv4.2 expression in cardiomyocytes. Iran J Basic Med Sci 25: 1201-1206. 36311192
Hogg, D.W., C.C. Casatti, D.D. Belsham, D. Baršytė-Lovejoy, and D.A. Lovejoy. (2022). Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, : A potential antagonist of corticotropin-releasing factor (CRF). Biochem Biophys Rep 32: 101397. 36467544
Hogg, D.W., M. Husić, D. Wosnick, T. Dodsworth, A.L. D''Aquila, and D.A. Lovejoy. (2019). Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuron.al Function and Behavior in Mammals. Front Neurosci 13: 581. 31417336
Huang, S. and S. Qian. (2022). Advances in otolith-related protein research. Front Neurosci 16: 956200. 35958995
Hung, C.H., X. Qiao, P.T. Lee, and M.G. Lee. (2004). Clathrin-dependent targeting of receptors to the flagellar pocket of procyclic-form Trypanosoma brucei. Eukaryot. Cell. 3: 1004-1014. 15302833
Iorio, J., C. Duranti, T. Lottini, E. Lastraioli, G. Bagni, A. Becchetti, and A. Arcangeli. (2020). K11.1 Potassium Channel and the Na/H Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells. Front Pharmacol 11: 848. 32587517
Ishii, Y., O. Muta, T. Teshima, N. Hirasima, M. Odaka, T. Fushimi, Y. Fujii, and N. Osakabe. (2021). Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation. Nutrients 13:. 34959764
Jensen, A.M.G., Y. Kitago, E. Fazeli, C.B. Vægter, S.A. Small, G.A. Petsko, and O.M. Andersen. (2023). Dimerization of the Alzheimer''s disease pathogenic receptor SORLA regulates its association with retromer. Proc. Natl. Acad. Sci. USA 120: e2212180120. 36652482
Jobst-Schwan, T., K.X. Knaup, R. Nielsen, T. Hackenbeck, M. Buettner-Herold, P. Lechler, S. Kroening, M. Goppelt-Struebe, U. Schloetzer-Schrehardt, B.G. Fürnrohr, R.E. Voll, K. Amann, K.U. Eckardt, E.I. Christensen, and M.S. Wiesener. (2013). Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am. J. Physiol. Renal Physiol 305: F734-744. 23825075
Kim, J. and A.J. Ricci. (2022). In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective. Proc. Natl. Acad. Sci. USA 119:. 35197290
Kinoshita, A., T. Shah, M.M. Tangredi, D.K. Strickland, and B.T. Hyman. (2003). The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278: 41182-41188. 12888553
Klar, J., J. Schuster, T.N. Khan, M. Jameel, K. Mäbert, L. Forsberg, S.A. Baig, S.M. Baig, and N. Dahl. (2015). Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans. J Med Genet 52: 599-606. 26142438
Klassen, R.B., K. Crenshaw, R. Kozyraki, P.J. Verroust, L. Tio, S. Atrian, P.L. Allen, and T.G. Hammond. (2004). Megalin mediates renal uptake of heavy metal metallothionein complexes. Am. J. Physiol. Renal Physiol 287: F393-403. 15126248
Kole, M.J., J. Qian, M.P. Waase, T.L. Klassen, T.T. Chen, G.J. Augustine, and J.L. Noebels. (2015). Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J. Neurosci. 35: 11433-11444. 26269648
Koppel, N., M.B. Friese, H.L. Cardasis, T.A. Neubert, and S.J. Burden. (2019). Vezatin is required for the maturation of the neuromuscular synapse. Mol. Biol. Cell 30: 2571-2583. 31411944
Kounnas, M.Z., R.E. Morris, M.R. Thompson, D.J. FitzGerald, D.K. Strickland, and C.B. Saelinger. (1992). The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J. Biol. Chem. 267: 12420-12423. 1618748
Kozyraki, R., M. Kristiansen, A. Silahtaroglu, C. Hansen, C. Jacobsen, N. Tommerup, P.J. Verroust, and S.K. Moestrup. (1998). The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 91: 3593-3600. 9572993
Kozyraki, R., P. Verroust, and O. Cases. (2022). Cubilin, the intrinsic factor-vitamin B12 receptor. Vitam Horm 119: 65-119. 35337634
Kzhyshkowska, J., S. Mamidi, A. Gratchev, E. Kremmer, C. Schmuttermaier, L. Krusell, G. Haus, J. Utikal, K. Schledzewski, J. Scholtze, and S. Goerdt. (2006). Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-3228. 16357325
Leupin, O., E. Piters, C. Halleux, S. Hu, I. Kramer, F. Morvan, T. Bouwmeester, M. Schirle, M. Bueno-Lozano, F.J. Fuentes, P.H. Itin, E. Boudin, F. de Freitas, K. Jennes, B. Brannetti, N. Charara, H. Ebersbach, S. Geisse, C.X. Lu, A. Bauer, W. Van Hul, and M. Kneissel. (2011). Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J. Biol. Chem. 286: 19489-19500. 21471202
Li, C., K. Zhang, G. Pan, L. Zhang, X. Hu, G. Zhao, C. Deng, M. Tan, C. Li, M. Xu, J. Su, L. Shen, S. Kausar, L. Yang, M.N. Abbas, and H. Cui. (2021). Bmintegrin β1: A broadly expressed molecule modulates the innate immune response of Bombyx mori. Dev Comp Immunol 114: 103869. 32950537
Lin, Z., J.Y. Tann, E.T. Goh, C. Kelly, K.B. Lim, J.F. Gao, and C.F. Ibanez. (2015). Structural basis of death domain signaling in the p75 neurotrophin receptor. Elife 4: e11692. 26646181
Loppinet, E., H.A. Besser, C.E. Lee, W. Zhang, B. Cui, and C. Khosla. (2023). Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. J. Am. Chem. Soc. 145: 18705-18710. 37590164
May, P. and J. Herz. (2003). LDL receptor-related proteins in neurodevelopment. Traffic 4: 291-301. 12713657
May, P., Y.K. Reddy, and J. Herz. (2002). Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277: 18736-18743. 11907044
Meena, V., G. Kaur, R. Joon, V. Shukla, P. Choudhary, J.K. Roy, B. Singh, and A.K. Pandey. (2024). Transcriptome and biochemical analysis in hexaploid wheat with contrasting tolerance to iron deficiency pinpoints multi-layered molecular process. Plant Physiol. Biochem 207: 108336. [Epub: Ahead of Print] 38245990
Michishita, M., T. Ikeda, T. Nakashiba, M. Ogawa, K. Tashiro, T. Honjo, K. Doi, S. Itohara, and S. Endo. (2004). Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. Brain Res Dev Brain Res 153: 135-142. 15464227
Mishra, S., A. Knupp, M.P. Szabo, C.A. Williams, C. Kinoshita, D.W. Hailey, Y. Wang, O.M. Andersen, and J.E. Young. (2022). The Alzheimer''s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. Cell Mol Life Sci 79: 162. 35226190
Mitsuishi, Y., H. Hasegawa, A. Matsuo, W. Araki, T. Suzuki, S. Tagami, M. Okochi, M. Takeda, R. Roepman, and M. Nishimura. (2010). Human CRB2 inhibits γ-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J. Biol. Chem. 285: 14920-14931. 20299451
Miyazono, K., A. Olofsson, P. Colosetti, and C.H. Heldin. (1991). A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO. J. 10: 1091-1101. 2022183
Mizuno, A., T. Toyama, A. Ichikawa, N. Sakai, Y. Yoshioka, Y. Nishito, R. Toga, H. Amesaka, T. Kaneko, K. Arisawa, R. Tsutsumi, Y. Mita, S.I. Tanaka, N. Noguchi, and Y. Saito. (2023). An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase. J. Biol. Chem. 299: 105009. 37406814
Mori, S., T. Ito, H. Takao, F. Shimokawa, and K. Terao. (2023). Optically driven microtools with an antibody-immobilised surface for on-site cell assembly. IET Nanobiotechnol. [Epub: Ahead of Print] 36647211
Niclou, S.P., L. Jia, and J.A. Raper. (2000). Slit2 is a repellent for retinal ganglion cell axons. J. Neurosci. 20: 4962-4974. 10864954
Nishida-Fukuda, H., R. Araki, M. Shudou, H. Okazaki, Y. Tomono, H. Nakayama, S. Fukuda, T. Sakaue, Y. Shirakata, K. Sayama, K. Hashimoto, M. Detmar, S. Higashiyama, and S. Hirakawa. (2016). Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J. Biol. Chem. 291: 10490-10500. 26966180
Nishimune, H. and K. Shigemoto. (2018). Practical Anatomy of the Neuromuscular Junction in Health and Disease. Neurol Clin 36: 231-240. 29655446
Olson, G.E., V.P. Winfrey, K.E. Hill, and R.F. Burk. (2008). Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J. Biol. Chem. 283(11): 6854-6860. 18174160
P, X., L. Zz, J. Gg, W. Lp, B. Cm, W. Yl, M.F. Chen, and L. W. (2022). The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus. Neurochem Int 105417. [Epub: Ahead of Print] 36067928
Paul, N.R., G. Jacquemet, and P.T. Caswell. (2015). Endocytic Trafficking of Integrins in Cell Migration. Curr. Biol. 25: R1092-1105. 26583903
Polacheck, W.J., M.L. Kutys, J. Yang, J. Eyckmans, Y. Wu, H. Vasavada, K.K. Hirschi, and C.S. Chen. (2017). A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552: 258-262. 29160307
Potla, R., M. Hirano-Kobayashi, H. Wu, H. Chen, A. Mammoto, B.D. Matthews, and D.E. Ingber. (2020). Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis. J Cell Sci. [Epub: Ahead of Print] 32989042
Prevo, R., S. Banerji, J. Ni, and D.G. Jackson. (2004). Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). J. Biol. Chem. 279: 52580-52592. 15345716
Pupovac, A. and R. Sluyter. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cell Mol Life Sci. [Epub: Ahead of Print] 27180276
Qi, Q., L. Chen, H. Sun, N. Zhang, J. Zhou, Y. Zhang, X. Zhang, L. Li, D. Li, and L. Wang. (2022). Low-density lipoprotein receptor deficiency reduced bone mass in mice via the c-fos/NFATc1 pathway. Life Sci 310: 121073. 36244411
Ray, T.A., K.J. Cochran, and J.N. Kay. (2019). The Enigma of CRB1 and CRB1 Retinopathies. Adv Exp Med Biol 1185: 251-255. 31884620
Reiss, M., N. Viebig, S. Brecht, M.N. Fourmaux, M. Soete, M. Di Cristina, J.F. Dubremetz, and D. Soldati. (2001). Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii. J. Cell Biol. 152: 563-578. 11157983
Romeo, R., K. Glotzbach, A. Scheller, and A. Faissner. (2020). Deletion of LRP1 From Astrocytes Modifies Neuron.al Network Activity in an Model of the Tripartite Synapse. Front Cell Neurosci 14: 567253. 33519378
Saint-Jean, B., E. Seveno-Carpentier, C. Alcon, J.M. Neuhaus, and N. Paris. (2010). The cytosolic tail dipeptide Ile-Met of the pea receptor BP80 is required for recycling from the prevacuole and for endocytosis. Plant Cell 22: 2825-2837. 20807880
Saouros, S., B. Edwards-Jones, M. Reiss, K. Sawmynaden, E. Cota, P. Simpson, T.J. Dowse, U. Jäkle, S. Ramboarina, T. Shivarattan, S. Matthews, and D. Soldati-Favre. (2005). A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex. J. Biol. Chem. 280: 38583-38591. 16166092
Sawmynaden, K., S. Saouros, N. Friedrich, J. Marchant, P. Simpson, B. Bleijlevens, M.J. Blackman, D. Soldati-Favre, and S. Matthews. (2008). Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. EMBO Rep 9: 1149-1155. 18818666
Silva, J.P., V.G. Lelianova, Y.S. Ermolyuk, N. Vysokov, P.G. Hitchen, O. Berninghausen, M.A. Rahman, A. Zangrandi, S. Fidalgo, A.G. Tonevitsky, A. Dell, K.E. Volynski, and Y.A. Ushkaryov. (2011). Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Proc. Natl. Acad. Sci. USA 108: 12113-12118. 21724987
Skandalis, S.S. (2023). CD44 Intracellular Domain: A Long Tale of a Short Tail. Cancers (Basel) 15:. 37894408
Spille, D.C., E.C. Bunk, C. Thomas, Z. Özdemir, A. Wagner, B.H. Akkurt, M. Mannil, W. Paulus, O.M. Grauer, W. Stummer, V. Senner, and B. Brokinkel. (2023). Protoporphyrin IX (PpIX) Fluorescence during Meningioma Surgery: Correlations with Histological Findings and Expression of Heme Pathway Molecules. Cancers (Basel) 15:. 36612300
Suleiman, M., N. Abdulrahman, H. Yalcin, and F. Mraiche. (2018). The role of CD44, hyaluronan and NHE1 in cardiac remodeling. Life Sci 209: 197-201. 30089233
Sundararajan, T., A.M. Manzardo, and M.G. Butler. (2018). Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. Gene 641: 25-34. 29032150
Tepass, U., C. Theres, and E. Knust. (1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799. 2344615
Tufail, M. and M. Takeda. (2009). Insect vitellogenin/lipophorin receptors: molecular structures, role in oogenesis, and regulatory mechanisms. J Insect Physiol 55: 87-103. 19071131
Urata, Y., W. Saiki, Y. Tsukamoto, H. Sago, H. Hibi, T. Okajima, and H. Takeuchi. (2020). Xylosyl Extension of -Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. Cells 9:. 32423029
Wu, L.L., J.X. Zhou, Y.M. Jia, and H. Leng. (2023). Screening and bioinformatics analysis of senile osteoporosis genes based on GEO database. Eur Rev Med Pharmacol Sci 27: 4857-4864. 37318459
Xu, R., M. Zhu, J. Cao, and M. Guo. (2022). Tea Polyphenols Protect the Mammary Gland of Dairy Cows by Enhancing Antioxidant Capacity and Regulating the TGF-β1/p38/JNK Pathway. Metabolites 12:. 36355092
Yang, L. and L. Jiang. (2023). The seven rice vacuolar sorting receptors localize to prevacuolar compartments. J Plant Physiol. 291: 154137. 37984048
Yi, C., K.Y. Goh, L.W. Wong, A. Ramanujan, K. Tanaka, S. Sajikumar, and C.F. Ibáñez. (2021). Inactive variants of death receptor p75 reduce Alzheimer''s neuropathology by interfering with APP internalization. EMBO. J. 40: e104450. 33258176
Yi, S., S. Wang, Q. Zhao, C. Yao, Y. Gu, J. Liu, X. Gu, and S. Li. (2016). miR-sc3, a novel miRNA, promoted Schwann cell proliferation and migration by targeting Astn1. Cell Transplant. [Epub: Ahead of Print] 26786955
Yoshida, T., Y. Matsuda, Z. Naito, and T. Ishiwata. (2012). CD44 in human glioma correlates with histopathological grade and cell migration. Pathol Int 62: 463-470. 22726066
Yu, Z., L.E. Surface, C.Y. Park, M.A. Horlbeck, G.A. Wyant, M. Abu-Remaileh, T.R. Peterson, D.M. Sabatini, J.S. Weissman, and E.K. O''Shea. (2018). Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife 7:. 29745899
Yusuf, B., I. Mukovozov, S. Patel, Y.W. Huang, G.Y. Liu, E.C. Reddy, M. Skrtic, M. Glogauer, and L.A. Robinson. (2021). The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein. Sci Rep 11: 3614. 33574432
Zhang, P., C. Zhou, Q. Jing, Y. Gao, L. Yang, Y. Li, J. Du, X. Tong, and Y. Wang. (2023). Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy. Apoptosis. [Epub: Ahead of Print] 37634193