Tetraspan Junctional Complex Protein or MARVEL (4JC) Superfamily
Hua, V.B., A.B. Chang, J.H. Tchieu, N.M. Kumar, P.A. Nielsen, and M.H. Saier, Jr. (2003). Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. J. Membr. Biol. 194: 59-76; Attwood MM, Krishnan A, Pivotti V, Yazdi S, Almen MS, Schioth HB. Topology based identification and comprehensive classification of four-transmembrane helixcontaining proteins (4TMs) in the human genome. BMC Genomics. 2016 PMID: 27030248; Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier MH Jr. (2017). Characterization of the tetraspan junctional complex (4JC) superfamily. Biochim Biophys Acta. 2017 Mar;1859(3):402-414. PMID 27916633. This superfamily may also include TC# 1.A.101 and 1.A.138.
1.A.24 - The Gap Junction-forming Connexin (Connexin) Family1.A.36 - The Intracellular Chloride Channel (ICC) Family
1.A.64 - The Plasmolipin (Plasmolipin) Family
1.A.81 - The Low Affinity Ca2+ Channel (LACC) Family
1.A.82 - The LHFPL Tetraspan Protein (LTSP) Family
1.A.84 - The Calcium Homeostasis Modulator Ca2+ Channel (CALHM-C) Family
1.H.1 - The Claudin Tight Junction (Claudin1) Family
1.H.2 - The Invertebrate PMP22-Claudin (Claudin2) Family
8.A.16 - The Ca+ Channel Auxiliary Subunit γ1-γ8 (CCAγ) Family
9.A.27 - The Non-Classical Protein Exporter (NCPE) Family
9.A.46 - The Clarin (CLRN) Family
9.B.41 - The Occludin (Occludin) Family
9.B.130 - The Tetraspan Vesicle Membrane Protein (TVP) Family
9.B.179 - The MscS/DUF475 (DUF475) Family