TCDB is operated by the Saier Lab Bioinformatics Group

Tetraspan Junctional Complex Protein or MARVEL (4JC) Superfamily

Hua, V.B., A.B. Chang, J.H. Tchieu, N.M. Kumar, P.A. Nielsen, and M.H. Saier, Jr. (2003). Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. J. Membr. Biol. 194: 59-76; Attwood MM, Krishnan A, Pivotti V, Yazdi S, Almen MS, Schioth HB. Topology based identification and comprehensive classification of four-transmembrane helixcontaining proteins (4TMs) in the human genome. BMC Genomics. 2016 PMID: 27030248; Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier MH Jr. (2017). Characterization of the tetraspan junctional complex (4JC) superfamily. Biochim Biophys Acta. 2017 Mar;1859(3):402-414. PMID 27916633. This superfamily may also include TC# 1.A.101 and 1.A.138.

1.A.24 - The Gap Junction-forming Connexin (Connexin) Family
1.A.36 - The Intracellular Chloride Channel (ICC) Family
1.A.64 - The Plasmolipin (Plasmolipin) Family
1.A.81 - The Low Affinity Ca2+ Channel (LACC) Family
1.A.82 - The LHFPL Tetraspan Protein (LTSP) Family
1.A.84 - The Calcium Homeostasis Modulator Ca2+ Channel (CALHM-C) Family
1.H.1 - The Claudin Tight Junction (Claudin1) Family
1.H.2 - The Invertebrate PMP22-Claudin (Claudin2) Family
8.A.16 - The Ca+ Channel Auxiliary Subunit γ1-γ8 (CCAγ) Family
9.A.27 - The Non-Classical Protein Exporter (NCPE) Family
9.A.46 - The Clarin (CLRN) Family
9.B.41 - The Occludin (Occludin) Family
9.B.130 - The Tetraspan Vesicle Membrane Protein (TVP) Family
9.B.179 - The MscS/DUF475 (DUF475) Family