TCDB is operated by the Saier Lab Bioinformatics Group

9.B.179 The MscS/DUF475 (DUF475) Family

The DUF475 family consists of proteins primarily from Actinobacteria but possibly also Firmicutes.  They have 4 N-terminal TMSs that may be related to MARVEL domain containing proteins (TC# 1.A.64) and pantophysins (TC# 9.B.130). The hydrophilic C-terminal domain is G/Q/P-rich and redundant.