| 2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)
The UIT1 family is a constituent of the IT
superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st308/DctB family of Lolkema and
Slotboom (2003).
It consists of proteins from Gram-negative and Gram-positive bacteria
(e.g., Xanthomonas, Rhizobium and Streptomyces species).
The proteins are of about 450 aas with 12-14 putative TMSs. Closest
functionally-characterized homologues are in the DASS (TC #2.A.47)
family. One member of this family is a putative malonate transporter (An and Kim, 1998).
MatC is a part of the IT superfamily.
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This family belongs to the IT Superfamily.
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| References: |
An, J.H. and Y.S. Kim. (1998). A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. Eur J Biochem 257: 395-402.
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Lolkema, J.S. and D.J. Slotboom. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. J. Mol. Biol. 327: 901-909.
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Prakash, S., G. Cooper, S. Singhi, and M.H. Saier, Jr. (2003). The ion transporter superfamily. Biochim. Biophys. Acta. 1618: 79-92.
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Rabus, R., D.L. Jack, D.J. Kelly, and M.H. Saier, Jr. (1999). TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145(Pt12): 3431-3445.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 2.A.101.1.1 | Putative transporter, FkbF | Bacteria | FkbF of Streptomyces hygroscopicus var. ascomyceticus (Q9KIE8) |
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| 2.A.101.1.2 | The putative malonate uptake porter, MatC (An and Kim, 1998) (distantly related to members of the DASS family (2.A.47)) | Bacteria | MatC of Rhizobium leguminosarum bv trifolii (C6B3K0) |
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