8.B.22 The P-Conotoxin Cystine Knot (P-CCK) Family
The P-CCK family of spasmodic conotoxins consists of several toxins. The structure of a synthetic construct of such a protein has been determined (1IXT; Miles et al. 2002).
This family belongs to the Conotoxin Superfamily.
|Miles, L.A., C.Y. Dy, J. Nielsen, K.J. Barnham, M.G. Hinds, B.M. Olivera, G. Bulaj, and R.S. Norton. (2002). Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J. Biol. Chem. 277: 43033-43040.|
|Pi, C., J. Liu, C. Peng, Y. Liu, X. Jiang, Y. Zhao, S. Tang, L. Wang, M. Dong, S. Chen, and A. Xu. (2006). Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 88: 809-819.|
P-type conotoxin of 88 aas
Conotoxin of Conus gloriamaris
Conotoxin Rg9.1 of 90 aas.
Conotoxin Rg9.1 of Conus regius
Conotoxin of 27 aas
Conotoxin of Conus amadis
Conotoxin of 73 aas (Pi et al. 2006).
Conotoxin of Conus litteratus