9.B.142 The Integral membrane Glycosyltransferase family 39 (GT39) Family
Thousands of homologues of the GT39 family are found in bacteria, archaea and eukaryotes. These integral membrane proteins function in glycosyl transfer, but some such enzymes have been shown to transport their substrates across the membrane in which they reside. See TC families 4.D.1 and 4.D.2. These proteins may be distantly related to those in the GT39 family, TC# 9.B.142. Protein N-glycosylation in an Asgard archaeon, now called Promethearchaeum syntrophicum, has been characterized (Nakagawa et al. 2024).
References:
Putative transport protein of 503aas and 9 TMSs
Archaea
Putative transporter of Pyrococcus abyssi (Q9UZC2)
YYY membrane protein of 616aas and 15 TMSs
Archaea
YYY protein of Ferroglobus placidus (D3S2C5)
Putative ABC transporter (shows no sequence similarity to ABC proteins)
Bacteria
Putative ABC transporter of Corynebacterium efficiens (C8NRH5)
Putative ABC -2 transporter/glyceryl transferase
Bacteria
Putative ABC transporter of Rhodococcus erythropolis (C3JPH6)
Hypothetical membrane protein
Bacteria
Hypothetical protein of Thermomicrobium roseum
Hypothetical protein
Bacteria
HP of Terriglobus saanensis
Putative transporter/glycosyltransferase
Proteobacteria
Putative permease of Stigmatella aurantiaca
LphB (10 putative TMSs)
Bacteria
LphB of Legionella pneumophila (O87771)
Uncharacterized protein of 347 aas and 10 TMSs in an apparent 1 + 2 + 2 + 2 +2 + 1 TMS arrangement.
UP of Candidatus Woesebacteria bacterium
Uncharacterized protein of 536 aas and 10 - 12 TMSs.
UP of Sorangium cellulosum
Uncharacterized protein of 589 aas
Actinobacteria
UP of Amycolatopsis mediterranei
Uncharacterized protein of 524 aas and 11 TMSs
Archaea
UP of Methanobacterium formicicum
Uncharacterized protein of 549 aas
Acidobacteria
UP of Choracidobacterium thermophilum
Arabinofuranosyl transferase, AftB, of 575 aas and 13 TMSs
Actinobacteria
AftB of Amycolatopsis orientalis
Arabinofuranosyltransferase, AftB of 533 aas and 9 TMSs
Actinobacteria
AftB of Corynebacterium diphtheriae
Uncharacterized protein of 386 aas and 11 TMSs
UP of Streptomyces niveus
Uncharacterized protein of 370 aas and 10 TMSs.
UP of Pelotomaculum thermopropionicum
Uncharacterized protein of 328 aas and 10 TMSs.
UP of Candidatus Beckwithbacteria bacteriu
PMT_2 superfamily glycosyltransferase, family 39, ArnT, archaeo_STT3, of 604 aas and 12 TMSs.
GT family 39 member of Bdellovibrio bacteriovorus
Glycosyl transferase I, GtrI of 506 aas and 13 TMSs in a 1 + 12 TMS arrangment.
GtrI of Shigella flexneri
Putative glycosyl transferase, GtrI
GtrI of Salmonella enterica
Putative glycosyl transferase of the ArnT and PMT2 families
ArnT homologue of Candidatus Saccharibacteria bacterium
Uncharaterized protein of 579 aas and 10 TMSs.
UP of Lactobacillus casei
Uncharacterized protein of 593 aas and 14 TMSs
UP of Ornalilinea apprima
Uncharacterized protein of 543 aas and 11 TMSs in a 6 + 4 + 1 TMS arrangement
UP of Enterococcus silesiacus
Uncharacterized protein of 569 aas and 10 TMSs
UP of Terriglobus saanensis
Uncharacterized protein of 530 aas
UP of Escherichia fergusonii
Uncharacterized protein of 562 aas and 12 TMSs.
UP of Aeromonas caviae
Uncharacteerized protein of 863 aas and 14 TMSs
UP of Lachnospira pectinoschiza
Dolichyl-phosphate-mannose-protein mannosyltransferase of 749 aas and 14 TMSs
UP of Thermococcus peptonophilus
Glycosyl transferase of 503 aas and 11 TMSs.
GT of Candidatus Beckwithbacteria bacterium
Glycosyltransferase of 484 aas and 7 - 10 TMSs.
GT of Streptomyces corchorusii
Damage-inducible protein CinA of 512 aas and 9 TMSs.
CinA of Streptococcus pneumoniae
Uncharacterized protein of 455 aas and 9 - 10 TMSs.
UP of Candidatus Daviesbacteria bacterium
Uncharacterized protein of 465 aas and 9 - 11 TMSs.
UP of Flectobacillus major
Uncharacterized protein of 508 aas and 10 TMSs.
UP of Rubrobacter radiotolerans
Glycosyl transferase, family 39 of 535 aas and 12 TMSs.
GT of
Pedosphaera parvula
Uncharacterized protein of 341 aas and 7 - 10 TMSs.
UP of Methanocella conradii
Uncharacterized protein of 523 aas and 10 TMSs.
UP of Runella zeae
Uncharacterized protein of 400 aas and 9 TMSs.
UP of Candidatus Beckwithbacteria bacterium
DUF2029 domain-containing proteinof 504 aas.
DUF2029 protein of Actinoplanes atraurantiacus
Uncharacterized protein of 409 aas and 12 TMSs.
UP of Sphingomonas phyllosphaerae
Uncharacterized protein of 298 aas and 9 TMSs in a 1 + 4 + 4 TMS arrangement.
UP of Candidatus Peribacter riflensis
DUF2029 domain-containing protein of 398 aas and 12 TMSs in a 5 + 2 + 5 arrangement
DUF2029 protein of Agrococcus casei
Uncharacterized protein of 502 aas and 12 TMSs.
UP of Thermogemmatispora onikobensis
Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase, PimE of 410 aas and 10 TMSs. It is a polyprenol-phosphate-mannose α-mannosyltransferase in the Glycosyltransferase Family 87 (Morita et al. 2006; Belardinelli and Jackson 2017).
PimE of Mycobacterium smegmatis
DUF2339 domain-containing proteinof 637 aas and 19 TMSs.
DUF2339 protein of Rhodococcus fascians
DUF2029 domain-containing protein of 412 aas and 8 - 10 TM
DUF2029 protein of Caballeronia hypogeia
PigM of 825 aas and ~17 TMSs
PigM of Schizosaccharomyces cryophilus
Uncharacterized protein of 463 aas and 12 TMSs in a 9 + 3 TMS arrangement.
UP of Carnobacterium maltaromaticum
Uncharacterized protein of 472 aas and 12 TMSs in a 9 + 3 arrangement.
UP of Planococcaceae bacterium Storch
Uncharacterized protein of 430 aas and 12 TMSs in a 9 + 3 arrangement.
UP of Enterococcus mundtii
Uncharacterized protein of 472 aas and 12 TMSs in a 9 + 3 arrangement.
UP of Blautia sp. AF19-34
Uncharacterized protein of 537 aas and 12 TMSs in a 9 + 3 arrangement
UP of Acutalibacter muris
Uncharacterized protein of 463 aas and 12 TMSs in a 9 + 3 arrangement.
UP of Salilacibacter sp. NKC3-5
O-antigen ligase family protein of 520 aas and 12 TMSs in a 9 + 3 arrangement.
Ligase of Lactobacillus delbrueckii
Glycosyl transferase family 39 protein of 546aas and 13 TMSs
γ-Proteobacteria
GT39 family member of Acidithiobacillus caldus (C6NTX4)
4-Amino-4-deoxy-L-arabinose transferase, ArnT of the glycosyltransferase PMT family. The structure has been illucidated and the mechanism proposed (VI Petrou et al., Science, vol 351, pg 608, 2016).
ArnT of Cupriavidus metallidurans (Ralstonia metallidurans)
Uncharacterized protein of 807 aas and 17 TMSs in a 1 + 6 + 6 + 4 arrangement.
UP of Oscillochloris trichoides
Uncharacterized glycosyl transferase family 39 of 581 aas and 11 TMSs.
UP of Candidatus Wolfebacteria bacterium
Glycosyl transferase of 537 aas and 13 TMSs in a 1 + 6 + 6 arrangement.
GT of Mastigocladopsis repens
Uncharacterized protein of 565 aas and 13 TMSs
UP of Fibrella aestuarina
Uncharacterized protein of 485 aas
UP of Candidatus Magnetobacterium casensis
Uncharacterized protein of 563 aas and 11 - 12 TMSs
UP of Candidatus Peribacter riflensis
Phospholipid carrier-dependent glycosyltransferase of 608 aas and 12 TM
GT of Halostagnicola kamekurae
Uncharacterized protein of 459 aas and 11 TMSs
UP of Candidatus Amesbacteria bacterium
Uncharacterized protein of 448 aas and 13 TMSs.
UP of Candidatus Saccharibacteria bacterium
Putative undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, ArnT
Proteobacteria
ArnT of Enterobacter cloacae
Glycosyltransferase family 39 protein of 517 aas with 9 TMSs in a 1 + 2 + 2 + 4 TMS arrangement with a C-terminal 150 aa hydrophilic domain.
Glycosyl transferase of candidate division KSB1 bacterium (aquatic metagenome)
Glycosyl transferase family PMT
Bacterioidetes
Glycosyl transferase of Zobellia galactivorans
Putative glycosyltransferase
Bacteria
Putative glycosyltransferase of Hydrogenobacter thermophilus
Putative glycosyltransferase with 13 TMSs in a 1 + 6 + 6 TMS topology
Firmicutes
Putative glycosyltransferase of Gordonia rhizosphera
Glycosyl transferase family 39; 4-amino 4-deoxy L-arabinose transferase; Dolichyl phosphate-mannose:protein mannosyl transferase; PMT family; Pfam13231. 528 aas and 13 TMSs
Bacteroidetes
PMT family protein of Solitalea (Flexibacter) canadensis (UPI0003424A3D or YP_0080090676)
Uncharacterized protein of 446 aas.
Proteobacteria
Wzy of Francisella tularensis
Polymyxin resistance protein of 448 aas and 13 TMSs, ArnT. ArnT catalyzes incorporation of 4-amino-4-deoxy-l-arabinose (l-Ara4N) into the lipid A moiety of lipopolysaccharide (LPS) and is required for transport of LPS to the outer membrane (Tavares-Carreón et al. 2015). ArnT has a 13 TMS topology of key amino acids that contribute to its enzymatic function have been identified (Tavares-Carreón et al. 2015). In response to polymyxin exposure, differentially expressed genes in Acinetobacter baumannii have been identified (Li et al. 2020).
Proteobacteria
ArnT of Burkholderia cenocepacia
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, ArnT, of 550 aas and 13 TMSs. This modification of LPS is critical for enabling bacteria to resist killing by antimicrobial peptides (Tavares-Carreón et al. 2015).
ArnT of E. coli
Integral membrane serotype-specific glucosyltransferase, GtrV of 417 aas and 9 TMSs (Korres and Verma 2004).
GtrV of Shigella flexneri serotype 5b
Uncharacterized protein of 383 aas and 9 TMSs.
UP of Verrucomicrobia bacterium
Uncharacteerized protein of 432 aas and 10 - 13 TMSs.
UP of Mesorhizobium sp.
Unharacterized protein of 444 aas and 10 - 11 TMSs.
UP of Phormidium sp. GEM2.Bin31 (soda lake metagenome)
Uncharacterized protein of 416 aas and 9 - 11 TMSs.
UP of Lachnospiraceae bacterium (feces metagenome)
Uncharacterized protein of 515 aas and 9 TMSs.
UP of Pseudomonas citronellolis
Uncharacterized protein of 572 aas and 13 TMSs
UP of Thiotrichales bacterium HS_08
Uncharacterized protein of 465 aas and 9 - 11 TMSs
UP of Norcardia sp.
Membrane-bound dolichyl-phosphomannose mannosyltransferase of 814aas and 11-14 TMSs
Archaea
Mannosyltransferase of Thermococcus sibiricus (C6A142)
Uncharacterized protein of 472 aas and 11 TMSs.
Cyanobacteria
UP of Synechocystis sp PCC 6803
Undecaprenyl-diphosphooligosaccharide--protein glycotransferase, PglB. Oligosaccharyltransferase that catalyzes the transfer of a preassembled heptasaccharide from a lipid donor to an asparagine residue in nascent polypeptide chains, affording a beta-linked glycan to the asparagine side chain of target proteins. The x-ray structure is known (Lizak et al. 2011).
PglB of Campylobacter lari
Uncharacterized glycosyltransferase of 572 aas and 12 TMSs.
UP of Candidatus Beckwithbacteria bacterium
Mannosyl transferase of 739 aas, PMT_2.
PMT_2 of Methanosaeta harundinacea
The glycosyltransferase complex consisting of 8 subunits, all integral membrane proteins. The high resolution 3-dimensional structure has been elucidated (Wild et al. 2018). The catalytic subunit is the STT3 protein of 718 aas and 13 TMSs. The other subunits have 1 - 6 TMSs. The function of the complex is glycosylation of newly synthesized proteins on Asn with Glc3Man9 GlcNac2.
Glycosyltransferase complex of Saccharomyces cerevisiae
STT3, P39007, 718 aas amd 13 TMSs - the catalytic subunit
OST1 (Ribophorin I), P41543, 476 aas and 2 TMSs, N- and C-terminal
OST2 (Dad1), P46964, 130 aas and 3 C-terminal TMSs
OST3 (Tusc3), P48439, 350 aas and 6 TMSs in a 2 + 2 +2 arrangement; this protein is a member of the MagT1 family (TC# 1.A.76)
OST4, Q99380, 36 aas and 1 TMS
OST5, (TMEM258), Q92316, 86 aas and 2 TMSs
WBP1 (Ost48), P33767, 430 aas and 2 TMSs, one N-terminal, and one C-terminal
SWP1 (Ribophorin II), Q02795, 286 aas and 4 TMSs, in a 1 (N-terminal) and 3 (C-terminal) arrangement
Dolichyl-phosphooligosaccharide-protein glycotransferase, AglB of 1054 aas and 15 TMSs. This protein is involved in the pathway S-layer biogenesis (Abu-Qarn et al. 2007). AglB exhibits substrate promiscuity, being capable of processing a variety of lipid-linked glycans (Cohen-Rosenzweig et al. 2014).
AglB of Haloferax volcanii (Halobacterium volcanii)
Putative glycosyl transferase of 604 aas and 13 TMSs.
GT of Chloroflexi bacterium
OSTA/B (OST-A/OST-B) complex of 11 subunits. Most subunits are shared by both complexes except that OSTA has STT3A while OSTB has STT3B, and OSTA has DC2 while OSTB has two parologous Mg2+ porter proteins, MAGT1 (TC# 1.A.76.1) and TUSC3 (TC# 1.A.76.2). The oligosaccharyl transferase (OST) complex catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an
asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent
polypeptide chains, the first step in protein N-glycosylation.
N-Glycosylation occurs cotranslationally, and the complex associates with
the Sec61 complex at the channel-forming translocon complex that
mediates protein translocation across the endoplasmic reticulum (ER) membrane. Ribophorin I associates with a subset of membrane proteins after their integration at the Sec61 translocon (Wilson et al. 2005). All subunits are required for maximal enzyme activity. The SST3 subunit
contains the active site and the acceptor peptide and donor lipid-linked
oligosaccharide (LLO) binding pockets. STT3A is present
in the majority of OST complexes and mediates cotranslational
N-glycosylation of most sites on target proteins, while STT3B-containing
complexes are required for efficient post-translational glycosylation
and mediate glycosylation of sites that have been skipped by STT3A
(Ruiz-Canada et al. 2009). High-resolution cryo-EM structures of human OST-A and
OST-B have been described (Ramírez et al. 2019). Although the two complexes have similar overall architectures, structural
differences in the catalytic subunits, STT3A and STT3B, facilitate
contacts to distinct OST subunits, DC2 in OST-A and MAGT1 in OST-B. In
OST-A, interactions with TMEM258 and STT3A allow ribophorin-I to form a
four-helix bundle that can bind to a translating ribosome, whereas the
equivalent region is disordered in OST-B. An acceptor
peptide and dolichylphosphate are bound to STT3B, but only dolichylphosphate
is bound in STT3A, suggesting distinct affinities of the two OST complexes for
protein substrates (Ramírez et al. 2019).
The oligosaccharyl transferase (OST) complex of Homo sapiens
STT3A, 705 aas and 13 TMSs; P46977
STT3B (SIMP)13 TMSs in a 1 + 8 +3 + 1 TMS arrangement; Q8TCJ2
Ribophorin-I, RPN1, 607 aas and 4 TMSs in a 1 (N-terminus) + 3 TMS (C-terminus) arrangement; P04843
Ribophorin-2, RPN2, 631 aas and 2 or 3 TMSs; P04844
OST48 (DDOST), 456 aas and 2 TMSs, one N-terminal and one C-terminal, P39656
TMEM258, 79 aas and 2 TMSs; P61165
DAD1, 113 aas and 3 TMSs; P61803
OST4, 37 aas and 1 TMS; P0C6T2
DC2 or OSTC, an adaptor that mediates association with Sec61 for Ost-A
MAGT1, 335 aas and 5 TMSs in a 1 + 2 + 2 TMS arrangement; Q9H0U3
TUSC3, 348 AAS and 5 TMSs in a 1 + 2 + 2 TMS arrangement; Q13454
Uncharacterized proteini of 747 aas and 19 TMSs. It is possibly related to 9.B.14.
UP of Lokiarchaeum sp GC14-75
Putative glycosyltransferase
Archaea
Putative glycosyltransferase of Pyrococcus horikoshii
Putative glycosyltransferase with a topology of 13 TMSs
Animals
Putative glycosyltransferase of Trichoplax adhaerens (reptans)
Glycosyltransferase
Animals
Glycosyltransferase of Homo sapiens
Glycosyltransferase family 66
Fungi
Glycosyltransferase of Hypocrea atroviridis
Putative glycosyltransferase
Archaea
Putative glycosyltransferase of Methanococcus marpaludis
Putative glycosyltransferase
Firmicutes
Putative glycosyltransferase of Clostridium botulinum
Uncharacterized protein of 522 aas
Firmicutes
UP of Gemella haemolysans
The WlaF protein of 713 aas
Proteobacteria
WlaF of Campylobacter jejuni
Putative glycosyltransferase
Cyanobacteria
Putative glycosyltransferase of Nostoc azollae
Uncharacterized glycosyl transferase family 39 of 640 aas and 11 or 12 putative TMSs.
UP of Candidatus Wolfebacteria bacterium
Uncharacterized protein of 478 aas and 11 TMSs.
UP of Candidatus Woesebacteria bacterium
Uncharaterized glycosyltransferase of 470 aas and 11 TMSs
UP of Candidatus Beckwithbacteria bacterium
Uncharacterized glycosyltransferase of 471 aas and 11 TMSs
UP of Candidatus Beckwithbacteria bacterium
Uncharacterized protein of 514 aas and 11 TMSs
UP of Candidatus Roizmanbacteria bacterium (groundwater metagenome)
Uncharacterized glycosyltransferase of 536 aas and 15 TMSs.
Glycosyltransferase of Candidatus Heimdallarchaeota archaeon LC_3 (marine sediment metagenome)
Putative glycosyltransferase of 603 aas and 11 TMSs. In the PMF2 (Alg9-like) superfamily and the glycosyltransferase-22 superfamily.
Glycosyltransferase of Candidatus Heimdallarchaeota archaeon LC_3
Putative glycosyltransferase
Cyanobacteria
Putative glycosyltransferase of Arthrospira maxima (platensis)
Uncharacterized protein of 493 aas and 11 TMSs
Spirochaetes
UP of Leptospira interrogans
Uncharacterized protein of 825 aas and 11 TMSs
Cyanobacteria
UP of Lyngbya aestuarii
Glycosyl tranferase family 39 protein of 510 aas and 11 TMSs in a 1 + 6 + 4 TMS arrangement.
Euryarchaea
Glycosyl transferase of Methanoregula boonei
Uncharacterized protein of 614 aas and 13 TMSs in a 1 + 6 + 6 TMS arrangement.
Proteobacteria
UP of Desulfatibacillus alkenivorans
UP of 579 aas and 9 TMSs
Cyanobacteria
UP of Oscillatoria nigro-viridis
Uncharacterized protein of 566 aas and 9 TMSs in a 1 + 4 + 4 arrangement
Proteobacteria
UP of Syntrophobacter fumaroxidans
Glycosyl transferase famiy 39; 4-amino 4-deoxy L-arabinose transferase; Pfam13231. 566 aas and 11 TMSs.
Armatimonadetes (Bacteria)
Glycosyltransferase family 39 of Chthonomonas calidirosea
Putative glycosyltransferase of the PMT_2 family
Actinobacteria
Putative glycosyltransferase of Bifidobacterium animalis
Uncharacterized protein of 796 aas and 22 TMSs in a 6 + 6 + 6 + 4 arrangement.
UP of Candidatus Woesebacteria bacterium
Uncharacterized protein of 537 aas and 11 TMSs
UP of Candidatus Amesbacteria bacterium
Phospholipid carrier-dependent glycosyltransferase of 1090 aas and ~24 TMSs. Repeat sequences have been detected.
GT of Paenibacillus chitinolyticus
Putative dolichyl-phosphate-mannose--protein mannosyltransferase of 603 aas and 12 TMSs in a 1 + 6 + 5 arrangement.
GT of Butyribacterium methylotrophicum
The structure of the yeast O-mannosyltransferase Pmt1-Pmt2 complex has been determined at 3.2 Å resolution (Bai et al. 2019). In eukaryotes, a nascent peptide entering the endoplasmic reticulum (ER) is scanned by two Sec61 translocon-associated large membrane machines for protein N-glycosylation and protein O-mannosylation, respectively. The structures of both the eight-protein oligosaccharyltransferase complex and the mannosyltransferases of the PMT family have been determined. They function in ER protein homeostasis. Cryo-EM structures of the Saccharomyces cerevisiae Pmt1-Pmt2 complex bound to a donor and an acceptor peptide shows that each subunit contains 11 TMSs and a lumenal beta-trefoil fold termed the MIR domain. The structures reveal the substrate recognition site and confirms an inverting mannosyl-transferring reaction mechanism. The transmembrane domains of Pmt1 and Pmt2 share a structural fold with the catalytic subunits of oligosaccharyltransferases, confirming an evolutionary relationship between protein O-mannosylation and protein N-glycosylation (Bai et al. 2019).
Pmt1-Pmt2 complex of Saccharomyces cerevisiae
Glycosyltransferase family 39 with a probable 13 TMSs in a 1 + 6 + 6 TMS arrangement.
Acidobacteria
Glycosyltransferase of Terriglobus spanensis
3-amino 4-deoxy L-arabinose transferase-like protein of 524 aas
Firmicutes
Transferase of Thermincola potens
Putative glycosyl transferase of 443 aas and 11 TMSs (Hug et al. 2016).
Glycosyl transferase of Candidatus Peribacter riflensis
Uncharacterized protein of 477 aas and 11 TMSs
UP of Candidatus Desantisbacteria bacterium
Putative glycosyltransferase
Proteobacteria
Putative glycosyltransferase of Rhodopseudomonas palustris
Glycosyltransferase family 39 of 554 aas and 13 putative TMSs
Spirochaetes
Glycosyltransferase of Leptonema illini
Glycosyltransferase of 463 aas and 7 TMSs (family 39; the PMT_2 superfamily).
Planctomycetes
Glycosyltransferase of Rhodopirellula baltica
Uncharacterized protein with no conserved domain recognized by CDD. 527 aas and 9 - 10 TMSs in a 1 + 4 + 4 arrangement.
UP of Candidatus Beckwithbacteria bacterium
Uncharacterized protein of 565 aas and 9 - 12 TMSs.
UP of Candidatus Roizmanbacteria bacterium
Dolichyl-phosphate-mannose--protein mannosyltransferase of 502 aas and 11 TMSs.
MT of Leptospira vanthielii
Uncharacteerized protein of 511 aas and 11 TMSs.
UP of Clostridium baratii
Uncharacterized protein of 507 aas and 11 TMSs.
UP of Acetobacter tropicalis
Uncharacterized protein of 488 aas and 10 TMSs.
UP of Novosphingobium pentaromativorans
DUF2723 domain-containing protein of 1090 aas and 13 TMSs.
DUF2723 protein of Kordia periserrulae
DUF2029 domain-containing protein of 418 aas and 9 - 11 TMSs. Possibly a dolichyl-P-mannose mannosyl transferase. It is a member of the PMT_2 superfamily of mannosyltransferases.
DUF2029 protein of Adhaeribacter aquaticus
PMT_2 superfamily membeer of 424 aas and about 12 TMSs.
PMT_2 family member of Lokiarchaeum sp. GC14_75
Uncharacterized protein of 417 aas and 11 TMSs.
Acidobacteria
UP of Chloracidobacterium thermophilum
Glycosyltransferase family protein of 430 aas and 8 TMSs.
Firmicutes
UP of Clostridium thermocellum
Uncharacterized protein of 409 aas and 10 TMSs
Firmicutes
UP of Kyrpidia (Bacillus) tusciae
Uncharacterized protein of 542 aas and 10 TMSs
Acidobacteria
UP of Granulicella tundricola
Uncharacterized protein of 669 aas and 15 TMSs
Archaea
UP of Pyrococcus horikoshii
Uncharacterized DUF2070 domain protein of 688 aas and 15 TMSs.
UP of Anaerolinea thermolimosa
Uncharacterized protein of 523 aas and 9 TMSs with a 1 + 4 + 4 TMS pattern.
UP of Microgenomates bacterium
DUF2723 domain-containing protein of 455 aas and 9 TMSs in a 1 + 4 + 4 arrangement.
UP of Herpetosiphon geysericola