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1.A.14.2.1
The YccA protein, an inhibitor of FtsH. May share a similar mechanism of action as BI-1 in regulation apoptsis upon prolonged secretion stress (van Stelten et al., 2009).

Accession Number:P0AAC6
Protein Name:Inner membrane protein YccA aka B0970
Length:219
Molecular Weight:23363.00
Species:Escherichia coli [83333]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown, cations

Cross database links:

Genevestigator: P0AAC6 P0AAC6 P0AAC6
EchoBASE: EB1104 EB1104 EB1104
EcoGene: EG11113 EG11113 EG11113
eggNOG: COG0670 COG0670 COG0670
HEGENOM: HBG595196 HBG595196 HBG595196
DIP: DIP-47918N DIP-47918N DIP-47918N
RefSeq: AP_001600.1    NP_415490.1   
Entrez Gene ID: 946016   
Pfam: PF01027   
BioCyc: EcoCyc:EG11113-MONOMER    ECOL168927:B0970-MONOMER   
KEGG: ecj:JW0953    eco:b0970    ecj:JW0953    eco:b0970    ecj:JW0953    eco:b0970   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0043066 P:negative regulation of apoptosis
GO:0030162 P:regulation of proteolysis
GO:0043066 P:negative regulation of apoptotic process

References (23)

[1] “The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1.”  Tamura F.et.al.   6376117
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[6] “The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1.”  Tamura F.et.al.   6376117
[7] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[8] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[9] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[10] “Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA.”  Kihara A.et.al.   9636708
[11] “Dislocation of membrane proteins in FtsH-mediated proteolysis.”  Kihara A.et.al.   10357810
[12] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[13] “Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY.”  van Stelten J.et.al.   19661432
[14] “Quality control of cytoplasmic membrane proteins in Escherichia coli.”  Akiyama Y.et.al.   19454621
[15] “The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1.”  Tamura F.et.al.   6376117
[16] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[17] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[18] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[19] “Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA.”  Kihara A.et.al.   9636708
[20] “Dislocation of membrane proteins in FtsH-mediated proteolysis.”  Kihara A.et.al.   10357810
[21] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[22] “Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY.”  van Stelten J.et.al.   19661432
[23] “Quality control of cytoplasmic membrane proteins in Escherichia coli.”  Akiyama Y.et.al.   19454621

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FASTA formatted sequence
1:	MDRIVSSSHD RTSLLSTHKV LRNTYFLLSL TLAFSAITAT ASTVLMLPSP GLILTLVGMY 
61:	GLMFLTYKTA NKPTGIISAF AFTGFLGYIL GPILNTYLSA GMGDVIAMAL GGTALVFFCC 
121:	SAYVLTTRKD MSFLGGMLMA GIVVVLIGMV ANIFLQLPAL HLAISAVFIL ISSGAILFET 
181:	SNIIHGGETN YIRATVSLYV SLYNIFVSLL SILGFASRD