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1.A.15.1.6
NS channel protein-1 or Sec62 protein of 399aas and 2 TMSs.  Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation (Lakkaraju et al. 2012).

Accession Number:Q99442
Protein Name:Translocation protein SEC62
Length:399
Molecular Weight:45862.00
Species: [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q99442
HEGENOM: HBG379410
RefSeq: NP_003253.1   
Entrez Gene ID: 7095   
Pfam: PF03839   
OMIM: 602173  gene
KEGG: hsa:7095   

Gene Ontology

GO:0016235 C:aggresome
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0045111 C:intermediate filament cytoskeleton
GO:0005791 C:rough endoplasmic reticulum
GO:0008565 F:protein transporter activity
GO:0004872 F:receptor activity
GO:0006613 P:cotranslational protein targeting to membrane
GO:0055085 P:transmembrane transport

References (6)

[1] “Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1).”  Daimon M.et.al.   9020021
[2] “Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene.”  Daimon M.et.al.   10683767
[3] “Mammalian Sec61 is associated with Sec62 and Sec63.”  Meyer H.-A.et.al.   10799540
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[6] “Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.”  Han G.et.al.   18318008

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS KAVDCLLDSK 
61:	WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM KYDKDIKKEK DKGKAESGKE 
121:	EDKKSKKENI KDEKTKKEKE KKKDGEKEES KKEETPGTPK KKETKKKFKL EPHDDQVFLD 
181:	GNEVYVWIYD PVHFKTFVMG LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL 
241:	LAVARCILFL IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE 
301:	TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED DRSQHSSGNG 
361:	NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKS