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1.A.17.1.25
TMem16A or Anoctamin-1 (Ano1) Ca2+-activated anion (Cl-) channel of 960 aas and 10 TMSs.  Its structure has been solved by cryoEM (Paulino et al. 2017). The protein shows a similar organization to the fungal nhTMEM16, except for changes at the site of catalysis. There, the conformation of transmembrane helices, constituting a membrane-spanning furrow that provides a path for lipids in scramblases, is replaced to form an enclosed aqueous pore that is largely shielded from the membrane (Paulino et al. 2017). It thus provides a pathway for anions such as Cl-.

Accession Number:Q8BHY3
Protein Name:Anoctamin-1
Length:960
Molecular Weight:110916.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate inorgamic anions, chloride ions, Cl-

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FASTA formatted sequence
1:	MRVPEKYSTL PAEDRSVHIV NICAIEDLGY LPSEGTLLNS LSVDPDAECK YGLYFRDGKR 
61:	KVDYILVYHH KRASGSRTLA RRGLQNDMVL GTRSVRQDQP LPGKGSPVDA GSPEVPMDYH 
121:	EDDKRFRREE YEGNLLEAGL ELENDEDTKI HGVGFVKIHA PWHVLCREAE FLKLKMPTKK 
181:	VYHISETRGL LKTINSVLQK ITDPIQPKVA EHRPQTTKRL SYPFSREKQH LFDLTDRDSF 
241:	FDSKTRSTIV YEILKRTTCT KAKYSMGITS LLANGVYSAA YPLHDGDYEG DNVEFNDRKL 
301:	LYEEWASYGV FYKYQPIDLV RKYFGEKVGL YFAWLGAYTQ MLIPASIVGV IVFLYGCATV 
361:	DENIPSMEMC DQRYNITMCP LCDKTCSYWK MSSACATARA SHLFDNPATV FFSVFMALWA 
421:	ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV KDHPRAEYEA RVLEKSLRKE SRNKETDKVK 
481:	LTWRDRFPAY FTNLVSIIFM IAVTFAIVLG VIIYRISTAA ALAMNSSPSV RSNIRVTVTA 
541:	TAVIINLVVI ILLDEVYGCI ARWLTKIEVP KTEKSFEERL TFKAFLLKFV NSYTPIFYVA 
601:	FFKGRFVGRP GDYVYIFRSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM 
661:	KKFIRYLKLR RQSPSDREEY VKRKQRYEVD FNLEPFAGLT PEYMEMIIQF GFVTLFVASF 
721:	PLAPLFALLN NIIEIRLDAK KFVTELRRPV AIRAKDIGIW YNILRGVGKL AVIINAFVIS 
781:	FTSDFIPRLV YLYMYSQNGT MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVQICRYKD 
841:	YREPPWSEHK YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE 
901:	KVLMVELFMR EEQGKQQLLD TWMEKEKPRD VPCNNHSPTT HPEAGDGSPV PSYEYHGDAL