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1.A.20.1.1
BNip3 channel-forming protein (Bocharov et al., 2007)

Accession Number:Q12983
Protein Name:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 aka BNip3
Length:194
Molecular Weight:21541.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Single-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: Q12983
eggNOG: prNOG14892
RefSeq: NP_004043.2   
Entrez Gene ID: 664   
Pfam: PF06553   
OMIM: 603293  gene
KEGG: hsa:664   

Gene Ontology

GO:0030425 C:dendrite
GO:0031307 C:integral to mitochondrial outer membrane
GO:0005635 C:nuclear envelope
GO:0005654 C:nucleoplasm
GO:0046982 F:protein heterodimerization activity
GO:0042803 F:protein homodimerization activity
GO:0006338 P:chromatin remodeling
GO:0051607 P:defense response to virus
GO:0006309 P:DNA fragmentation involved in apoptosis
GO:0006917 P:induction of apoptosis
GO:0044419 P:interspecies interaction between organisms
GO:0045837 P:negative regulation of membrane potential
GO:0008634 P:negative regulation of survival gene produc...
GO:0051402 P:neuron apoptosis
GO:0006800 P:oxygen and reactive oxygen species metaboli...
GO:0046902 P:regulation of mitochondrial membrane permea...
GO:0001666 P:response to hypoxia

References (6)

[1] “Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.”  Boyd J.M.et.al.   7954800
[2] “The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.”  Chen G.et.al.   9396766
[3] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.”  Ohi N.et.al.   10381623
[6] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.”  Wang B.et.al.   19007248
Structure:
2J5D   2KA1   2KA2     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK 
61:	SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW 
121:	SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG 
181:	IYIGRRLTTS TSTF