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1.A.25.1.7
Innexin-6 protein, Inx-6 or Opu-6, of 389 aas and 4 TMSs. A single INX-6 gap junction channel consists of 16 subunits, a hexadecamer, in contrast to chordate connexin channels, which consist of 12 subunits. The channel pore diameters at the cytoplasmic entrance and extracellular gap region are larger than those of connexin26 (Oshima et al. 2016). Nevertheless, the arrangements of the transmembrane helices and extracellular loops of the INX-6 monomer are highly similar to those of connexin-26 (Cx26). The INX-6 gap junction channel comprises hexadecameric subunits but reveals an N-terminal pore funnel consistent with Cx26. The helix-rich cytoplasmic loop and C-terminus are intercalated through an octameric hemichannel, forming a dome-like entrance that interacts with N-terminal loops in the pore (Oshima et al. 2016).

Accession Number:Q9U3N4
Protein Name:Innexin-6
Length:389
Molecular Weight:45132.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

eggNOG: NOG281271
HEGENOM: HOG000113084
Entrez Gene ID: 178231   
Pfam: PF00876   
KEGG: cel:C36H8.2   

Gene Ontology

GO:0005921 C:gap junction
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055077 F:gap junction hemi-channel activity
GO:0005216 F:ion channel activity

References (2)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling.”  Starich T.A.et.al.   8707836

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASQVGAINS VNALISRVFV QPKGDLADRL NSRVTVVILA VSSALLLSSH FIGDPITCWT 
61:	PAQFNAQWVN FVNQYCFVHG TYFVPLDQQL AFEEEERTKV SIQYYQWVPY VFALQAFLFY 
121:	IPRFIWKAMI AYSGYDLAAA VKYVDRFWSE NRDKDDKFKT RLAAFEGRPS VYIWDGIRLA 
181:	RKKRSRNMAL FYTLSTVWQA VNAWIQFYIL TQLLDSSIYT LWGPSILGDL LQGNDWQTTG 
241:	HFPRIVHCDF NRRRPASVQL DTVLCVLTLN IYYEKLFIFL WFWLVFVAVV STVNCFKWIY 
301:	YLCNKTKAQK TIKNYLSTAP IKSTISDDQF FSALGEDGLF IMDQMALNLG DIPASYLTIS 
361:	MRNICQDFIE SEDYIDEERT PFVKSIKHT