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1.A.27.2.1
γ-subunit (proteolipid) of Na+,K+-ATPase, FXYD2.   Also functions as a cation-selective channel (Sha et al. 2008).

Accession Number:P54710
Protein Name:ATNG aka FXYD2 aka ATP1G1 aka ATP1C
Length:66
Molecular Weight:7283.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type III membrane protein2
Substrate ions

Cross database links:

Genevestigator: P54710
eggNOG: maNOG21430
RefSeq: NP_001120961.1    NP_001671.2    NP_067614.1   
Entrez Gene ID: 486   
Pfam: PF02038   
Drugbank: Drugbank Link   
OMIM: 154020  phenotype
601814  gene
KEGG: hsa:486   

Gene Ontology

GO:0005890 C:sodium:potassium-exchanging ATPase complex
GO:0005216 F:ion channel activity
GO:0005391 F:sodium:potassium-exchanging ATPase activity
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport

References (4)

[1] “Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit.”  Kim J.W.et.al.   9048881
[2] “Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase.”  Sweadner K.J.et.al.   11112438
[3] “Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit.”  Meij I.C.et.al.   11062458
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
2MKV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTGLSMDGGG SPKGDVDPFY YDYETVRNGG LIFAGLAFIV GLLILLSRRF RCGGNKKRRQ 
61:	INEDEP