TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.40.1.1
The ion channel viral protein U, Vpu. The mutation A18H converts a non-specific channel to a selective proton channel that is sensitive to rimantadine (Sharma et al., 2011).  Vpu forms stable pentamers (Padhi et al. 2013).  The mechanism of Vpu, a weakly conducting cation-selective channel that assists in detachment of the virion from infected cells, has been proposed (Padhi et al. 2014).  Interactions of Vpu with host cellular constituents have been reviewed (González 2015). Vpu forms large homo aggregates of 16 or 32 subunits (Lin et al. 2016).

Accession Number:P05919
Protein Name:Vpu
Length:81
Molecular Weight:9111.00
Species:Human immunodeficiency virus type 1 (HXB2 isolate) (HIV-1) [11706]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Host membrane1 / Single-pass type I membrane protein2
Substrate ions

Cross database links:

Pfam: PF00558   

Gene Ontology

GO:0005829 C:cytosol
GO:0005789 C:endoplasmic reticulum membrane
GO:0033644 C:host cell membrane
GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0006915 P:apoptosis
GO:0019059 P:initiation of viral infection
GO:0044419 P:interspecies interaction between organisms
GO:0006811 P:ion transport
GO:0019047 P:provirus integration
GO:0019076 P:release of virus from host

References (2)

[1] “Complete nucleotide sequences of functional clones of the AIDS virus.”  Ratner L.et.al.   3040055
[2] “The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels.”  Ewart G.D.et.al.   8794357
Structure:
2N29     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	QPIPIVAIVA LVVAIIIAIV VWSIVIIEYR KILRQRKIDR LIDRLIERAE DSGNESEGEI 
61:	SALVEMGVEM GHHAPWDVDD L