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1.A.42.1.1
Vpr of HIV of 96 aas and one C-terminal TMS.  Vpr forms a cation-selective ion channel within the plasma membrane. The C-terminal helix (residues 56-77) effectively forms the transmembrane region, while the N-terminal helix exhibited an amphipathic nature by associating horizontally with a single leaflet (Majumder et al. 2024).  Various oligomeric states (ranging from tetramer to heptamer) were considered to form the Vpr ion channel, and a pentamer was favored. 

Accession Number:P12520
Protein Name:VPR
Length:96
Molecular Weight:11379.00
Species:Human immunodeficiency virus type 1 (New York-5 isolate) (HIV-1) [11698]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Virion1
Substrate cation, inorganic cation

Cross database links:

Pfam: PF00522   

Gene Ontology

GO:0005829 C:cytosol
GO:0043655 C:extracellular space of host
GO:0042025 C:host cell nucleus
GO:0005758 C:mitochondrial intermembrane space
GO:0019012 C:virion
GO:0005216 F:ion channel activity
GO:0006915 P:apoptosis
GO:0007049 P:cell cycle
GO:0019059 P:initiation of viral infection
GO:0044419 P:interspecies interaction between organisms
GO:0006811 P:ion transport
GO:0019047 P:provirus integration
GO:0045449 P:regulation of transcription
GO:0006350 P:transcription

References (4)

[1] “Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.”  Piller S.C.et.al.   8552585
[2] “Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.”  Wang L.et.al.   8921884
[3] “Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest.”  Yao S.et.al.   9851370
[4] “Structure of human immunodeficiency virus type 1 Vpr(34-51) peptide in micelle containing aqueous solution.”  Engler A.et.al.   12084067
Structure:
1BDE   1DSJ   1DSK   1KZS   1KZT   1KZV   5JK7     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEQAPEDQGP QREPYNEWTL ELLEELKSEA VRHFPRIWLH NLGQHIYETY GDTWAGVEAI 
61:	IRILQQLLFI HFRIGCRHSR IGVTRQRRAR NGASRS