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1.A.51.1.1
The voltage-gated proton channel, mVSOP (269 aas) (Sasaki et al., 2006).  A hydrophobic plug functions as the gate (Chamberlin et al. 2013).

Accession Number:Q3U2S8
Protein Name:Voltage-gated hydrogen channel 1
Length:269
Molecular Weight:31242.00
Species: [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Genevestigator: Q3U2S8
eggNOG: roNOG15859
HEGENOM: HBG714522
DIP: DIP-46134N
RefSeq: NP_001035954.1    NP_083028.1   
Entrez Gene ID: 74096   
Pfam: PF00520   
KEGG: mmu:74096   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030171 F:voltage-gated proton channel activity
GO:0015992 P:proton transport
GO:0009268 P:response to pH
GO:0010043 P:response to zinc ion
GO:0055085 P:transmembrane transport

References (3)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “A voltage sensor-domain protein is a voltage-gated proton channel.”  Sasaki M.et.al.   16556803
Structure:
3VMX   3VMY   3VMZ   3VN0   3VYI   3WKV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTSHDPKAVT RRTKVAPTKR MSRFLKHFTV VGDDYHTWNV NYKKWENEEE EEEPAPTSAE 
61:	GEGNAEGPDA EAGSASTPRQ SLDFRSRLRK LFSSHRFQVI IICLVVLDAL LVLAELLLDL 
121:	KIIEPDEQDY AVTAFHYMSF AILVFFMLEI FFKIFVFRLE FFHHKFEILD AFVVVVSFVL 
181:	DLVLLFKSHH FEALGLLILL RLWRVARIIN GIIISVKTRS ERQILRLKQI NIQLATKIQH 
241:	LEFSCSEKEQ EIERLNKLLK QNGLLGDVN