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1.A.51.2.1
The voltage-sensor containing phosphatase, VSP, of 576 aas and 4 TMSs N-terminal to the phosphatase domain. The enzyme region of VSP contains the phosphatase and C2 domains, is structurally similar to the tumor suppressor phosphatase PTEN, and catalyzes the dephosphorylation of phosphoinositides. The transmembrane voltage sensor is connected to the phosphatase through a short linker region, and phosphatase activity is induced upon membrane depolarization. The coupling between the two domains has been studied (Sakata et al. 2017).  

Accession Number:Q4W8A1
Protein Name:Voltage-sensor containing phosphatase
Length:576
Molecular Weight:65211.00
Species:Ciona intestinalis (Transparent sea squirt) [7719]
Number of TMSs:3
Substrate

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FASTA formatted sequence
1:	MEGFDGSDFS PPADLVGVDG AVMRNVVDVT INGDVTAPPK AAPRKSESVK KVHWNDVDQG 
61:	PSEKPETRQE ERIDIPEISG LWWGENEHGV DDGRMEIPTT GVGRVQFRVR AVIDHLGMRV 
121:	FGVFLIFLDI ILMIIDLSLP GKSESSQSFY DGMALALSCY FMLDLGLRIF AYGPKNFFTN 
181:	PWEVADGLII VVTFVVTIFY TVLDEYVQET GADGLGRLVV LARLLRVVRL ARIFYSHQQM 
241:	KASSRRTISQ NKRRYRKDGF DLDLTYVTDH VIAMSFPSSG RQSLFRNPIG EVSRFFKTKH 
301:	PDKFRIYNLC SERGYDETKF DNHVYRVMID DHNVPTLVDL LKFIDDAKVW MTSDPDHVIA 
361:	IHCKGGKGRT GTLVSSWLLE DGKFDTAKEA LEYFGSRRTD FEVGDVFQGV ETASQIRYVG 
421:	YFEKIKKNYG GQLPPMKKLK VTGVTITAIQ GVGRGNGSDL SMQIVSERQE VLLCKFAEGY 
481:	NCALQYDATD DCVTCEVKNC PVLAGDIKVR FMSTSKSLPR GYDNCPFYFW FNTSLVEGDH 
541:	VTLKREEIDN PHKKKTWKIY RDNFTVKLTF SDAEDI