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1.A.77.1.5
Fungal MCU homologue of 493 aas and 2 TMS. The cryo-electron microscopy structure of the full-length MCU to an overall resolution of ~3.7 Å has been determined (Yoo et al. 2018). The structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of the MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore (Yoo et al. 2018).

Accession Number:Q7S4I4
Protein Name:Predicted protein
Length:493
Molecular Weight:56997.00
Species:Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [367110]
Number of TMSs:2
Substrate Mg2+, Ca2+

Cross database links:

eggNOG: fuNOG07561 fuNOG07561
Entrez Gene ID: 3875796   
Pfam: PF04678   
KEGG: ncr:NCU08166    ncr:NCU08166   

References (2)

[1] “The genome sequence of the filamentous fungus Neurospora crassa.”  Galagan J.E.et.al.   12712197
[2] “The genome sequence of the filamentous fungus Neurospora crassa.”  Galagan J.E.et.al.   12712197

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNCVRMRLQC RLMPSSNTLA RWCLESPQKN LTLHRPRISN VALRQASTSV SPKTRETEAE 
61:	AKAKKLDQKR LDEHEEEVRA REQQVRRPWH REGADKPPVE GNADPIAKGK LLTTPTRLLK 
121:	LILPLPLRVE KDQKNNGRNN EYGRSISLNS DIQPLALLIH PQQPLSYVER LIQAELPPVV 
181:	ENGQEKIPNV YFRAEDSEQG DQKPTSRAEA RSKDDGGEPS EYNTNLSHVA SYSGLGHRGP 
241:	KRSSQDKRWV RWSSSTEMGD FIRDAARGRE FAIEIEGYNI EMRVSVPSFG DRTYYMRQRL 
301:	RKMSSEIDGL AKIKHECDLL AHRSAHRLAK GGFGLLAGWW GVVYYVTFHT EFGWDLVEPV 
361:	TYLAGLTTIM GGYLWFLYIN KDLSYKAAMN VTVSRRQHAL YEMKGFDIER WEQLVQDANA 
421:	LRREIRVIAV EYDVDWDETR DVGEDVKDVL DEERSRRDDE HRSIEKEKDE KFTEDEKRKR 
481:	KKDKESKETS GDS