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1.B.54.1.1
γ-Intimin (Eae protein) (934 aas; Wentzel et al., 2001)

Accession Number:P43261
Protein Name:Eae
Length:934
Molecular Weight:101836.00
Species:Escherichia coli [83334]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Single-pass membrane protein2
Substrate proteins

Cross database links:

HEGENOM: HBG468012
RefSeq: NP_290259.1    NP_312586.1   
Entrez Gene ID: 915471    960862   
Pfam: PF02369    PF02368    PF07979    PF01476   
BioCyc: ECOL83334:ECS4559-MONOMER   
KEGG: ece:Z5110    ecs:ECs4559   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0007155 P:cell adhesion
GO:0016998 P:cell wall macromolecule catabolic process
GO:0009405 P:pathogenesis

References (8)

[1] “Cloning and characterization of the eae gene of enterohaemorrhagic Escherichia coli O157:H7.”  Yu J.et.al.   1552854
[2] “Cloning and nucleotide sequence of the eae gene homologue from enterohemorrhagic Escherichia coli serotype O157:H7.”  Beebakhee G.et.al.   1577255
[3] “Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7.”  Perna N.T.et.al.   9673266
[4] “Molecular evolution and mosaic structure of alpha, beta, and gamma intimins of pathogenic Escherichia coli.”  McGraw E.A.et.al.   10331248
[5] “Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.”  Perna N.T.et.al.   11206551
[6] “Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.”  Hayashi T.et.al.   11258796
[7] “Cloning and nucleotide sequence of a gene upstream of the eaeA gene of enterohemorrhagic Escherichia coli O157:H7.”  Zhao S.et.al.   8566710
[8] “Sequence heterogeneity of the eae gene and detection of verotoxin-producing Escherichia coli using serotype-specific primers.”  Louie M.et.al.   8005211
Structure:
2ZQK   2ZWK   4E1S   3NCW   3NCX     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MITHGCYTRT RHKHKLKKTL IMLSAGLGLF FYVNQNSFAN GENYFKLGSD SKLLTHDSYQ 
61:	NRLFYTLKTG ETVADLSKSQ DINLSTIWSL NKHLYSSESE MMKAAPGQQI ILPLKKLPFE 
121:	YSALPLLGSA PLVAAGGVAG HTNKLTKMSP DVTKSNMTDD KALNYAAQQA ASLGSQLQSR 
181:	SLNGDYAKDT ALGIAGNQAS SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDSEKM 
241:	LAFGQVGARY IDSRFTANLG AGQRFFLPAN MLGYNVFIDQ DFSGDNTRLG IGGEYWRDYF 
301:	KSSVNGYFRM SGWHESYNKK DYDERPANGF DIRFNGYLPS YPALGAKLIY EQYYGDNVAL 
361:	FNSDKLQSNP GAATVGVNYT PIPLVTMGID YRHGTGNEND LLYSMQFRYQ FDKSWSQQIE 
421:	PQYVNELRTL SGSRYDLVQR NNNIILEYKK QDILSLNIPH DINGTEHSTQ KIQLIVKSKY 
481:	GLDRIVWDDS ALRSQGGQIQ HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN 
541:	NVQLTITVLS NGQVVDQVGV TDFTADKTSA KADNADTITY TATVKKNGVA QANVPVSFNI 
601:	VSGTATLGAN SAKTDANGKA TVTLKSSTPG QVVVSAKTAE MTSALNASAV IFFDQTKASI 
661:	TEIKADKTTA VANGKDAIKY TVKVMKNGQP VNNQSVTFST NFGMFNGKSQ TQATTGNDGR 
721:	ATITLTSSSA GKATVSATVS DGAEVKATEV TFFDELKIDN KVDIIGNNVR GELPNIWLQY 
781:	GQFKLKASGG DGTYSWYSEN TSIATVDASG KVTLNGKGSV VIKATSGDKQ TVSYTIKAPS 
841:	YMIKVDKQAY YADAMSICKN LLPSTQTVLS DIYDSWGAAN KYSHYSSMNS ITAWIKQTSS 
901:	EQRSGVSSTY NLITQNPLPG VNVNTPNVYA VCVE