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1.B.54.1.2
Invasin 985aas (Gal-Mor et al., 2008) (crystal structure of the c-terminal passenger domain has been solved; Hamburger et al., 1999)

Accession Number:P11922
Protein Name:Invasin aka YPTB1668
Length:985
Molecular Weight:106544.00
Species:Yersinia pseudotuberculosis [633]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell surface1
Substrate proteins

Cross database links:

HEGENOM: HBG757706
RefSeq: YP_070195.1   
Entrez Gene ID: 2953776   
Pfam: PF02369    PF07979   
Drugbank: Drugbank Link   
BioCyc: YPSE273123:YPTB1668-MONOMER   
KEGG: yps:YPTB1668   

Gene Ontology

GO:0009986 C:cell surface
GO:0005488 F:binding
GO:0007155 P:cell adhesion
GO:0009405 P:pathogenesis

References (4)

[1] “Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells.”  Isberg R.R.et.al.   3304658
[2] “Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.”  Chain P.S.G.et.al.   15358858
[3] “Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.”  Leong J.M.et.al.   1693333
[4] “Crystal structure of invasin: a bacterial integrin-binding protein.”  Hamburger Z.A.et.al.   10514372
Structure:
1CWV   4E1T     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVFQPISEFL LIRNAGMSMY FNKIISFNII SRIVICIFLI CGMFMAGASE KYDANAPQQV 
61:	QPYSVSSSAF ENLHPNNEME SSINPFSASD TERNAAIIDR ANKEQETEAV NKMISTGARL 
121:	AASGRASDVA HSMVGDAVNQ EIKQWLNRFG TAQVNLNFDK NFSLKESSLD WLAPWYDSAS 
181:	FLFFSQLGIR NKDSRNTLNL GVGIRTLENG WLYGLNTFYD NDLTGHNHRI GLGAEAWTDY 
241:	LQLAANGYFR LNGWHSSRDF SDYKERPATG GDLRANAYLP ALPQLGGKLM YEQYTGERVA 
301:	LFGKDNLQRN PYAVTAGINY TPVPLLTVGV DQRMGKSSKH ETQWNLQMNY RLGESFQSQL 
361:	SPSAVAGTRL LAESRYNLVD RNNNIVLEYQ KQQVVKLTLS PATISGLPGQ VYQVNAQVQG 
421:	ASAVREIVWS DAELIAAGGT LTPLSTTQFN LVLPPYKRTA QVSRVTDDLT ANFYSLSALA 
481:	VDHQGNRSNS FTLSVTVQQP QLTLTAAVIG DGAPANGKTA ITVEFTVADF EGKPLAGQEV 
541:	VITTNNGALP NKITEKTDAN GVARIALTNT TDGVTVVTAE VEGQRQSVDT HFVKGTIAAD 
601:	KSTLAAVPTS IIADGLMAST ITLELKDTYG DPQAGANVAF DTTLGNMGVI TDHNDGTYSA 
661:	PLTSTTLGVA TVTVKVDGAA FSVPSVTVNF TADPIPDAGR SSFTVSTPDI LADGTMSSTL 
721:	SFVPVDKNGH FISGMQGLSF TQNGVPVSIS PITEQPDSYT ATVVGNTAGD VTITPQVDTL 
781:	ILSTLQKKIS LFPVPTLTGI LVNGQNFATD KGFPKTIFKN ATFQLQMDND VANNTQYEWS 
841:	SSFTPNVSVN DQGQVTITYQ TYSEVAVTAK SKKFPSYSVS YRFYPNRWIY DGGTSLVSSL 
901:	EASRQCQGSD MSAVLESSRA TNGTRAPDGT LWGEWGSLTA YSSDWQSGEY WVKKTSTDFE 
961:	TMNMDTGALV QGPAYLAFPL CALAI