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1.B.9.1.1
Fatty acid outer membrane porin. Gated by high affinity ligand (fatty acid) binding which causes conformational changes in the N-terminus that open up a channel for substrate diffusion (Lepore et al., 2011).  May function in the transport of phenylpropanoids (resveratrol, naringenin and rutin) (Zhou et al. 2014).

Accession Number:P10384
Protein Name:FadL aka TTR aka B2344
Length:446
Molecular Weight:48542.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate resveratrol, Rutin, Naringenin

Cross database links:

Genevestigator: P10384
EchoBASE: EB0276
EcoGene: EG10280
eggNOG: COG2067
HEGENOM: HBG576860
RefSeq: AP_002944.1    NP_416846.2   
Entrez Gene ID: 946820   
Pfam: PF03349   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:EG10280-MONOMER    ECOL168927:B2344-MONOMER   
KEGG: ecj:JW2341    eco:b2344   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0009597 P:detection of virus
GO:0046718 P:entry of virus into host cell
GO:0006869 P:lipid transport

References (7)

[1] “Primary sequence of the Escherichia coli fadL gene encoding an outer membrane protein required for long-chain fatty acid transport.”  Black P.N.et.al.   1987139
[2] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Nucleotide sequencing and expression of the fadL gene involved in long-chain fatty acid transport in Escherichia coli.”  Said B.et.al.   2840553
[6] “Protein complexes of the Escherichia coli cell envelope.”  Stenberg F.et.al.   16079137
[7] “Crystal structure of the long-chain fatty acid transporter FadL.”  van den Berg B.et.al.   15178802
Structure:
1T16   1T1L   2R4L   2R4N   2R4O   2R4P   2R88   2R89   2R8A   3DWN   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD DAGNVSRNPA 
61:	LITMFDRPTF SAGAVYIDPD VNISGTSPSG RSLKADNIAP TAWVPNMHFV APINDQFGWG 
121:	ASITSNYGLA TEFNDTYAGG SVGGTTDLET MNLNLSGAYR LNNAWSFGLG FNAVYARAKI 
181:	ERFAGDLGQL VAGQIMQSPA GQTQQGQALA ATANGIDSNT KIAHLNGNQW GFGWNAGILY 
241:	ELDKNNRYAL TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP TATGGATQSG YLTLNLPEMW 
301:	EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY RIALGTTYYY 
361:	DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY AFNKDASVDV GVSYMHGQSV 
421:	KINEGPYQFE SEGKAWLFGT NFNYAF