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1.C.12.1.13
Intermedilysin of 532 aas and 1 N-terminal TMS.  It binds to membranes containing the human protein CD59 but forms pores only if the membrane contains sufficient cholesterol (Heuck et al. 2007).  CD59 is required for the specific coordination of intermedilysin (ILY) monomers and for triggering collapse of an oligomeric prepore. Movement of Domain 2 with respect to Domain 3 of ILY is essential for forming a late prepore intermediate that releases CD59, while the role of cholesterol may be limited to insertion of the TMSs (Boyd et al. 2016).

Accession Number:Q9LCB8
Protein Name:Intermedilysin
Length:532
Molecular Weight:58423.00
Species:Streptococcus intermedius [1338]
Number of TMSs:1
Substrate small molecules, large molecules

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTKQNIARK LSRVVLLSTL VLSSAAPISA AFAETPTKPK AAQTEKKTEK KPENSNSEAA 
61:	KKALNDYIWG LQYDKLNILT HQGEKLKNHS SREAFHRPGE YVVIEKKKQS ISNATSKLSV 
121:	SSANDDRIFP GALLKADQSL LENLPTLIPV NRGKTTISVN LPGLKNGESN LTVENPSNST 
181:	VRTAVNNLVE KWIQNYSKTH AVPARMQYES ISAQSMSQLQ AKFGADFSKV GAPLNVDFSS 
241:	VHKGEKQVFI ANFRQVYYTA SVDSPNSPSA LFGSGITPTD LINRGVNSKT PPVYVSNVSY 
301:	GRAMYVKFET TSKSTKVQAA IDAVVKGAKL KAGTEYENIL KNTKITAVVL GGNPGEASKV 
361:	ITGNIDTLKD LIQKGSNFSA QSPAVPISYT TSFVKDNSIA TIQNNTDYIE TKVTSYKDGA 
421:	LTLNHDGAFV ARFYVYWEEL GHDADGYETI RSRSWSGNGY NRGAHYSTTL RFKGNVRNIR 
481:	VKVLGATGLA WEPWRLIYSK NDLPLVPQRN ISTWGTTLHP QFEDKVVKDN TD