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1.C.24.1.1
Class IIa bacteriocin Pediocin PA-1 precursor of 62 aas.  Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. The specific receptor acts as a docking molecule, not as a structural piece of the pore, if the bacteriocin is anchored to the membrane (Ríos Colombo et al. 2019).

Accession Number:P29430
Protein Name:PPA1 aka PEDA aka PAPA aka PAP
Length:62
Molecular Weight:6644.00
Species:Pediococcus acidilactici [1254]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

RefSeq: NP_857602.1   
Entrez Gene ID: 1090329   
Pfam: PF01721   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium

References (4)

[1] “Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0.”  Marugg J.D.et.al.   1514784
[2] “Complete nucleotide sequence of pSMB 74, a plasmid encoding the production of pediocin AcH in Pediococcus acidilactici.”  Motlagh A.M.et.al.   7764941
[3] “Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0.”  Henderson J.T.et.al.   1575516
[4] “Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici.”  Lozano J.C.N.et.al.   1402795
Structure:
5UKZ     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKIEKLTEK EMANIIGGKY YGNGVTCGKH SCSVDWGKAT TCIINNGAMA WATGGHQGNH 
61:	KC