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1.C.47.1.2
Phormicin precursor

Accession Number:P10891
Protein Name:DEFI
Length:94
Molecular Weight:10110.00
Species:Protophormia terraenovae (Black blowfly) (Nestling-sucking blowfly) [34676]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, ions

Cross database links:

Pfam: PF01097   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042742 P:defense response to bacterium
GO:0045087 P:innate immune response

References (5)

[1] “Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae.”  Dimarcq J.-L.et.al.   2369900
[2] “Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.”  Lambert J.et.al.   2911573
[3] “Determination of disulfide bridges in natural and recombinant insect defensin A.”  Lepage P.et.al.   2013293
[4] “Progress in multidimensional NMR investigations of peptide and protein 3-D structures in solution. From structure to functional aspects.”  Bonmatin J.-M.et.al.   1467342
[5] “Refined three-dimensional solution structure of insect defensin A.”  Cornet B.et.al.   7663941
Structure:
1ICA     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFFMVFVVT FCLAVCFVSQ SLAIPADAAN DAHFVDGVQA LKEIEPELHG RYKRATCDLL 
61:	SGTGINHSAC AAHCLLRGNR GGYCNGKGVC VCRN