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1.G.4.1.2 The Ross River virus 6K protein. The class II fusion peptide is residues 896 - 914 (Apellániz et al. 2014). The 6K protein transports monovalent cations and Ca²⁺ (Hyser and Estes 2015).
Accession Number:	P08491
Protein Name:	Structural polyprotein
Length:	1254
Molecular Weight:	138468.00
Species:	Ross river virus (strain T48) (RRV) [11032]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Host cell membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+), monoatomic monocation

Structure:
Pfam:	PF01589 PF00943 PF01563 PF00944
Gene Ontology GO:0030430 C:host cell cytoplasm GO:0020002 C:host cell plasma membrane GO:0016021 C:integral to membrane GO:0019028 C:viral capsid GO:0019031 C:viral envelope GO:0055036 C:virion membrane GO:0004252 F:serine-type endopeptidase activity GO:0005198 F:structural molecule activity GO:0006508 P:proteolysis
References (4) [1] “Ross River virus 26 s RNA: complete nucleotide sequence and deduced sequence of the encoded structural proteins.” Dalgarno L.et.al. 6310876 [2] “Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA.” Ou J.-H.et.al. 6291034 [3] “Genetic stability of Ross River virus during epidemic spread in nonimmune humans.” Burness A.T.H.et.al. 2849242 [4] “An evolutionary tree relating eight alphaviruses, based on amino-terminal sequences of their glycoproteins.” Bell J.R.et.al. 6087344
6VYV

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MNYIPTQTFY GRRWRPRPAF RPWQVSMQPT PTMVTPMLQA PDLQAQQMQQ LISAVSALTT 
61:	KQNVKAPKGQ RQKKQQKPKE KKENQKKKPT QKKKQQQKPK PQAKKKKPGR RERMCMKIEN 
121:	DCIFEVKLDG KVTGYACLVG DKVMKPAHVK GTIDNPDLAK LTYKKSSKYD LECAQIPVHM 
181:	KSDASKYTHE KPEGHYNWHH GAVQYSGGRF TIPTGAGKPG DSGRPIFDNK GRVVAIVLGG 
241:	ANEGARTALS VVTWTKDMVT RVTPEGTEEW SAALMMCILA NTSFPCSSPP CYPCCYEKQP 
301:	EQTLRMLEDN VNRPGYYELL EASMTCRNRS RHRRSVTEHF NVYKATRPYL AYCADCGDGY 
361:	FCYSPVAIEK IRDEAPDGML KIQVSAQIGL DKAGTHAHTK IRYMAGHDVQ ESKRDSLRVY 
421:	TSAACSIHGT MGHFIVAHCP PGDYLKVSFE DADSHVKACK VQYKHDPLPV GREKFVVRPH 
481:	FGVELPCTSY QLTTAPTDEE IDMHTPPDIP DRTLLSQTAG NVKITAGGRT IRYNCTCGRD 
541:	NVGTTSTDKT INTCKIDQCH AAVTSHDKWQ FTSPFVPRAD QTARRGKVHV PFPLTNVTCR 
601:	VPLARAPDVT YGKKEVTLRL HPDHPTLFSY RSLGAEPHPY EEWVDKFSER IIPVTEEGIE 
661:	YQWGNNPPVR LWAQLTTEGK PHGWPHEIIQ YYYGLYPAAT IAAVSGASLM ALLTLAATCC 
721:	MLATARRKCL TPYALTPGAV VPLTLGLLCC APRANAASFA ETMAYLWDEN KTLFWMEFAA 
781:	PAAALALLAC CIKSLICCCK PFSFLVLLSL GASAKAYEHT ATIPNVVGFP YKAHIERNGF 
841:	SPMTLQLEVV ETSWEPTLNL EYITCEYKTV VPSPFIKCCG TSECSSKEQP DYQCKVYTGV 
901:	YPFMWGGAYC FCDSENTQLS EAYVDRSDVC KHDHASAYKA HTASLKATIR ISYGTINQTT 
961:	EAFVNGEHAV NVGGSKFIFG PISTAWSPFD NKIVVYKDDV YNQDFPPYGS GQPGRFGDIQ 
1021:	SRTVESKDLY ANTALKLSRP SPGVVHVPYT PTPSGFKYWL KEKGSSLNTK APFGCKIKTN 
1081:	PVRAMDCAVG SIPVSMDIPD SAFTRVVDAP AVTDLSCQVV VCTHSSDFGG VATLSYKTDK 
1141:	PGKCAVHSHS NVATLQEATV DVKEDGKVTV HFSTASASPA FKVSVCDAKT TCTAACEPPK 
1201:	DHIVPYGASH NNQVFPDMSG TAMTWVQRLA SGLGGLALIA VVVLVLVTCI TMRR

1.G.4.1.2
The Ross River virus 6K protein. The class II fusion peptide is residues 896 - 914 (Apellániz et al. 2014). The 6K protein transports monovalent cations and Ca²⁺ (Hyser and Estes 2015).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

1.G.4.1.2The Ross River virus 6K protein. The class II fusion peptide is residues 896 - 914 (Apellániz et al. 2014). The 6K protein transports monovalent cations and Ca2+ (Hyser and Estes 2015).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

1.G.4.1.2
The Ross River virus 6K protein. The class II fusion peptide is residues 896 - 914 (Apellániz et al. 2014). The 6K protein transports monovalent cations and Ca²⁺ (Hyser and Estes 2015).