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1.G.4.1.2
The Ross River virus 6K protein.  The class II fusion peptide is residues 896 - 914 (Apellániz et al. 2014).  The 6K protein transports monovalent cations and Ca2+ (Hyser and Estes 2015).

Accession Number:P08491
Protein Name:Structural polyprotein
Length:1254
Molecular Weight:138468.00
Species:Ross river virus (strain T48) (RRV) [11032]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Host cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+, monovalent cations

Cross database links:

Pfam: PF01589    PF00943    PF01563    PF00944   

Gene Ontology

GO:0030430 C:host cell cytoplasm
GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0019028 C:viral capsid
GO:0019031 C:viral envelope
GO:0055036 C:virion membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0005198 F:structural molecule activity
GO:0006508 P:proteolysis

References (4)

[1] “Ross River virus 26 s RNA: complete nucleotide sequence and deduced sequence of the encoded structural proteins.”  Dalgarno L.et.al.   6310876
[2] “Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA.”  Ou J.-H.et.al.   6291034
[3] “Genetic stability of Ross River virus during epidemic spread in nonimmune humans.”  Burness A.T.H.et.al.   2849242
[4] “An evolutionary tree relating eight alphaviruses, based on amino-terminal sequences of their glycoproteins.”  Bell J.R.et.al.   6087344

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNYIPTQTFY GRRWRPRPAF RPWQVSMQPT PTMVTPMLQA PDLQAQQMQQ LISAVSALTT 
61:	KQNVKAPKGQ RQKKQQKPKE KKENQKKKPT QKKKQQQKPK PQAKKKKPGR RERMCMKIEN 
121:	DCIFEVKLDG KVTGYACLVG DKVMKPAHVK GTIDNPDLAK LTYKKSSKYD LECAQIPVHM 
181:	KSDASKYTHE KPEGHYNWHH GAVQYSGGRF TIPTGAGKPG DSGRPIFDNK GRVVAIVLGG 
241:	ANEGARTALS VVTWTKDMVT RVTPEGTEEW SAALMMCILA NTSFPCSSPP CYPCCYEKQP 
301:	EQTLRMLEDN VNRPGYYELL EASMTCRNRS RHRRSVTEHF NVYKATRPYL AYCADCGDGY 
361:	FCYSPVAIEK IRDEAPDGML KIQVSAQIGL DKAGTHAHTK IRYMAGHDVQ ESKRDSLRVY 
421:	TSAACSIHGT MGHFIVAHCP PGDYLKVSFE DADSHVKACK VQYKHDPLPV GREKFVVRPH 
481:	FGVELPCTSY QLTTAPTDEE IDMHTPPDIP DRTLLSQTAG NVKITAGGRT IRYNCTCGRD 
541:	NVGTTSTDKT INTCKIDQCH AAVTSHDKWQ FTSPFVPRAD QTARRGKVHV PFPLTNVTCR 
601:	VPLARAPDVT YGKKEVTLRL HPDHPTLFSY RSLGAEPHPY EEWVDKFSER IIPVTEEGIE 
661:	YQWGNNPPVR LWAQLTTEGK PHGWPHEIIQ YYYGLYPAAT IAAVSGASLM ALLTLAATCC 
721:	MLATARRKCL TPYALTPGAV VPLTLGLLCC APRANAASFA ETMAYLWDEN KTLFWMEFAA 
781:	PAAALALLAC CIKSLICCCK PFSFLVLLSL GASAKAYEHT ATIPNVVGFP YKAHIERNGF 
841:	SPMTLQLEVV ETSWEPTLNL EYITCEYKTV VPSPFIKCCG TSECSSKEQP DYQCKVYTGV 
901:	YPFMWGGAYC FCDSENTQLS EAYVDRSDVC KHDHASAYKA HTASLKATIR ISYGTINQTT 
961:	EAFVNGEHAV NVGGSKFIFG PISTAWSPFD NKIVVYKDDV YNQDFPPYGS GQPGRFGDIQ 
1021:	SRTVESKDLY ANTALKLSRP SPGVVHVPYT PTPSGFKYWL KEKGSSLNTK APFGCKIKTN 
1081:	PVRAMDCAVG SIPVSMDIPD SAFTRVVDAP AVTDLSCQVV VCTHSSDFGG VATLSYKTDK 
1141:	PGKCAVHSHS NVATLQEATV DVKEDGKVTV HFSTASASPA FKVSVCDAKT TCTAACEPPK 
1201:	DHIVPYGASH NNQVFPDMSG TAMTWVQRLA SGLGGLALIA VVVLVLVTCI TMRR