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1.G.8.1.1
Preglycoprotein polyprotein (GP) complex. Contains (1) regional peptide, (2) GPI, and (3) GP2. (2 N-terminal TMSs) (Igonet et al., 2011).

Accession Number:P09991
Protein Name:Pre-glycoprotein polyprotein GP complex
Length:498
Molecular Weight:56131.00
Species:Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) [11624]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF00798   

Gene Ontology

GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0019031 C:viral envelope
GO:0055036 C:virion membrane
GO:0044419 P:interspecies interaction between organisms

References (10)

[1] “Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus.”  Southern P.J.et.al.   3824905
[2] “Virus-lymphocyte interactions. IV. Molecular characterization of LCMV Armstrong (CTL+) small genomic segment and that of its variant, Clone 13 (CTL-).”  Salvato M.et.al.   3259346
[3] “Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence.”  Grande-Perez A.et.al.   16051837
[4] “Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA.”  Flatz L.et.al.   16537369
[5] “Acidic pH triggers LCMV membrane fusion activity and conformational change in the glycoprotein spike.”  Di Simone C.et.al.   8291229
[6] “Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.”  Cao W.et.al.   9851928
[7] “Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins.”  Eschli B.et.al.   16731928
[8] “Mapping the landscape of the lymphocytic choriomeningitis virus stable signal peptide reveals novel functional domains.”  Saunders A.A.et.al.   17376927
[9] “Arenavirus Z-glycoprotein association requires Z myristoylation but not functional RING or late domains.”  Capul A.A.et.al.   17581989
[10] “Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell.”  Rojek J.M.et.al.   17761532

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGQIVTMFEA LPHIIDEVIN IVIIVLIVIT GIKAVYNFAT CGIFALISFL LLAGRSCGMY 
61:	GLKGPDIYKG VYQFKSVEFD MSHLNLTMPN ACSANNSHHY ISMGTSGLEL TFTNDSIISH 
121:	NFCNLTSAFN KKTFDHTLMS IVSSLHLSIR GNSNYKAVSC DFNNGITIQY NLTFSDAQSA 
181:	QSQCRTFRGR VLDMFRTAFG GKYMRSGWGW TGSDGKTTWC SQTSYQYLII QNRTWENHCT 
241:	YAGPFGMSRI LLSQEKTKFF TRRLAGTFTW TLSDSSGVEN PGGYCLTKWM ILAAELKCFG 
301:	NTAVAKCNVN HDAEFCDMLR LIDYNKAALS KFKEDVESAL HLFKTTVNSL ISDQLLMRNH 
361:	LRDLMGVPYC NYSKFWYLEH AKTGETSVPK CWLVTNGSYL NETHFSDQIE QEADNMITEM 
421:	LRKDYIKRQG STPLALMDLL MFSTSAYLVS IFLHLVKIPT HRHIKGGSCP KPHRLTNKGI 
481:	CSCGAFKVPG VKTVWKRR