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1.G.8.1.2
Pre-glycoprotein polyprotein (precursor), GPC (York and Nunberg, 2009).

Accession Number:P26313
Protein Name:Pre-glycoprotein polyprotein GP complex
Length:485
Molecular Weight:55607.00
Species:Junin arenavirus (JUNV) [11619]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF00798   

Gene Ontology

GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0019031 C:viral envelope
GO:0055036 C:virion membrane
GO:0044419 P:interspecies interaction between organisms

References (5)

[1] “Molecular organization of Junin virus S RNA: complete nucleotide sequence, relationship with other members of the Arenaviridae and unusual secondary structures.”  Ghiringhelli P.D.et.al.   1654373
[2] “The signal peptide of the Junin arenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex.”  York J.et.al.   15367645
[3] “Role of the stable signal peptide and cytoplasmic domain of G2 in regulating intracellular transport of the Junin virus envelope glycoprotein complex.”  Agnihothram S.S.et.al.   16698999
[4] “Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses.”  Radoshitzky S.R.et.al.   17287727
[5] “Involvement of cellular proteins in Junin arenavirus entry.”  Martinez M.G.et.al.   19548229
Structure:
2L0Z   5EN2     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGQFISFMQE IPTFLQEALN IALVAVSLIA IIKGVVNLYK SGLFQFFVFL ALAGRSCTEE 
61:	AFKIGLHTEF QTVSFSMVGL FSNNPHDLPL LCTLNKSHLY IKGGNASFKI SFDDIAVLLP 
121:	EYDVIIQHPA DMSWCSKSDD QIWLSQWFMN AVGHDWYLDP PFLCRNRTKT EGFIFQVNTS 
181:	KTGINENYAK KFKTGMHHLY REYPDSCLDG KLCLMKAQPT SWPLQCPLDH VNTLHFLTRG 
241:	KNIQLPRRSL KAFFSWSLTD SSGKDTPGGY CLEEWMLVAA KMKCFGNTAV AKCNLNHDSE 
301:	FCDMLRLFDY NKNAIKTLND ETKKQVNLMG QTINALISDN LLMKNKIREL MSVPYCNYTK 
361:	FWYVNHTLSG QHSLPRCWLI KNNSYLNISD FRNDWILESD FLISEMLSKE YSDRQGKTPL 
421:	TLVDICFWST VFFTASLFLH LVGIPTHRHI RGEACPLPHR LNSLGGCRCG KYPNLKKPTV 
481:	WRRGH