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2.A.20.2.3
Gibbon ape leukemia virus receptor 2/sodium-dependent phosphate transporter, Pi:Na+ symporter, PiT2, PiT-2, GLVR2, SLC20A2. Mapping of the minimal transporting unit suggested a structure universal to all PiT-related proteins (Battger and Pedersen, 2011).The protein can transport Pi in the absence of Na+, and mutations allow Na+ transport in the absence of Pi. Transmembrane amino acids E(55) and E(575) appear to be responsible for linking Pi import to Na+symport (Bøttger et al. 2006). transport in PiT2.

Accession Number:Q08357
Protein Name:GLVR2
Length:652
Molecular Weight:70392.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate phosphate, Na+

Cross database links:

Genevestigator: Q08357 Q08357
eggNOG: prNOG09374 COG0306
HEGENOM: HBG681698 HOG000231892
RefSeq: NP_006740.1   
Entrez Gene ID: 6575   
Pfam: PF01384   
OMIM: 158378  gene
KEGG: hsa:6575    hsa:6575   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005315 F:inorganic phosphate transmembrane transport...
GO:0004872 F:receptor activity
GO:0005436 F:sodium:phosphate symporter activity
GO:0044419 P:interspecies interaction between organisms
GO:0006817 P:phosphate transport
GO:0006814 P:sodium ion transport
GO:0005315 F:inorganic phosphate transmembrane transporter activity

References (23)

[1] “A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.”  van Zeijl M.et.al.   8302848
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor.”  Salauen C.et.al.   11356966
[5] “The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion.”  Chien M.L.et.al.   9151850
[6] “Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2.”  Sugai J.et.al.   11435563
[7] “Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.”  Boettger P.et.al.   12205090
[8] “Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.”  Boettger P.et.al.   15955065
[9] “Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.”  Boettger P.et.al.   16790504
[10] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[11] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[12] “A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.”  van Zeijl M.et.al.   8302848
[13] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor.”  Salauen C.et.al.   11356966
[16] “The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion.”  Chien M.L.et.al.   9151850
[17] “Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2.”  Sugai J.et.al.   11435563
[18] “Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.”  Boettger P.et.al.   12205090
[19] “Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.”  Boettger P.et.al.   15955065
[20] “Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.”  Boettger P.et.al.   16790504
[21] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[22] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[23] “Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.”  Wang C.et.al.   22327515

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FASTA formatted sequence
1:	MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV 
61:	LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG 
121:	STIGFSLVAI GTKGVQWMEL VKIVASWFIS PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL 
181:	RALPVFYAAT IAINVFSIMY TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR 
241:	KITGKLQKEG ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG 
301:	TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD SGLYKDLLHK 
361:	IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA TFRAADSSAP EDSEKLVGDT 
421:	VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG GVEMKLASEL ADPDQPREDP AEEEKEEKDA 
481:	PEVHLLFHFL QVLTACFGSF AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG 
541:	GVGICTGLWV WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG 
601:	SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP YV