8.A.141.1.1
Eros chaparone protein of 468 aas and one N-terminal TMS. In response to extracellular ATP, the purinergic receptor P2X7 (1.A.7.1.3) mediates various biological processes, including phosphatidylserine (PtdSer) exposure, phospholipid scrambling, dye uptake, ion transport, and IL-1beta production. Eros in mice is absolutely required for P2X7 function in all of these capacities. It probably functions as a chaparone protein for the insertion and assembly of this system as well as others (Ryoden et al. 2020).
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| Accession Number: | Q96HE7 |
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| Protein Name: | ERO1-like protein alpha |
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| Length: | 468 |
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| Molecular Weight: | 54393.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Peripheral membrane protein2 / Lumenal side3 |
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| Substrate |
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1: MGRGWGFLFG LLGAVWLLSS GHGEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR
61: LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY
121: SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD
181: LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL
241: CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR
301: LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE
361: NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL
421: IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH