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8.A.245.1.3
Vascular endothelial growth factor C (4), VEGF4, of 419aas and 1 N-terminal TMS. It is a growth factor active in angiogenesis as well as endothelial cell growth, stimulating their proliferation and migration. It also has effects on the permeability of blood vessels, and may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. It also plays a role in the maintenance of differentiated lymphatic endothelium in adults, and binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.

Accession Number:P49767
Protein Name:VEGF
Length:419
Molecular Weight:46883.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

DIP: DIP-5747N
RefSeq: NP_005420.1   
Entrez Gene ID: 7424   
Pfam: PF00341   
OMIM: 601528  gene
KEGG: hsa:7424   

Gene Ontology

GO:0016020 C:membrane
GO:0031093 C:platelet alpha granule lumen
GO:0008083 F:growth factor activity
GO:0001525 P:angiogenesis
GO:0051781 P:positive regulation of cell division
GO:0007165 P:signal transduction
GO:0006929 P:substrate-bound cell migration

References (9)

[1] “A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.”  Joukov V.et.al.   8617204
[2] “”  Joukov V.et.al.   8612600
[3] “Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.”  Lee J.et.al.   8700872
[4] “Characterization of murine Flt4 ligand/VEGF-C.”  Fitz L.J.et.al.   9247316
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Proteolytic processing regulates receptor specificity and activity of VEGF-C.”  Joukov V.et.al.   9233800
[9] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang Z.et.al.   15340161
Structure:
2X1W   2X1X   4BSK     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MHLLGFFSVA CSLLAAALLP GPREAPAAAA AFESGLDLSD AEPDAGEATA YASKDLEEQL 
61:	RSVSSVDELM TVLYPEYWKM YKCQLRKGGW QHNREQANLN SRTEETIKFA AAHYNTEILK 
121:	SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY 
181:	LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRRSLP ATLPQCQAAN 
241:	KTCPTNYMWN NHICRCLAQE DFMFSSDAGD DSTDGFHDIC GPNKELDEET CQCVCRAGLR 
301:	PASCGPHKEL DRNSCQCVCK NKLFPSQCGA NREFDENTCQ CVCKRTCPRN QPLNPGKCAC 
361:	ECTESPQKCL LKGKKFHHQT CSCYRRPCTN RQKACEPGFS YSEEVCRCVP SYWKRPQMS