8.A.88.1.1
Calciquestrin (CASQ) of 396 aas and 1 TMS. Calsequestrin is a high-capacity (~80 Ca2+ ions), moderate
affinity, calcium-binding protein and thus acts as an internal calcium
store in muscle. Calcium ions are bound by clusters of acidic residues
at the protein surface, often at the interface between subunits. Regulates the release of lumenal Ca2+ via the calcium release channel RYR1; thus playing a role in triggering muscle contraction (Sanchez et al. 2012).
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| Accession Number: | P31415 |
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| Protein Name: | Calsequestrin-1 |
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| Length: | 396 |
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| Molecular Weight: | 45160.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Sarcoplasmic reticulum1 |
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| Substrate |
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1: MSATDRMGPR AVPGLRLALL LLLVLGTPKS GVQGQEGLDF PEYDGVDRVI NVNAKNYKNV
61: FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK
121: LGLTEVDSMY VFKGDEVIEY DGEFSADTIV EFLLDVLEDP VELIEGEREL QAFENIEDEI
181: KLIGYFKSKD SEHYKAFEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPV
241: TIPDKPNSEE EIVNFVEEHR RSTLRKLKPE SMYETWEDDM DGIHIVAFAE EADPDGFEFL
301: ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSVWME
361: MDDEEDLPSA EELEDWLEDV LEGEINTEDD DDDDDD