TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.B.11.1.2
APETx2 toxin (42 aas) (an acid-sensing sodium channel toxin) (Shiomi, 2009).

Accession Number:P61542
Protein Name:APETx2
Length:42
Molecular Weight:4567.00
Species:Anthopleura elegantissima [6110]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Pfam: PF07936   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042151 C:nematocyst
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (2)

[1] “A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.”  Diochot S.et.al.   15044953
[2] “Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels.”  Chagot B.et.al.   15987885
Structure:
1WXN   2MUB     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	GTACSCGNSK GIYWFYRPSC PTDRGYTGSC RYFLGTCCTP AD